Assessment of Exploratory Activity and Anxiety in Rats with Different Levels of Impulsive Behavior
- 101 Downloads
Selection of a pedal to obtain reinforcement depending on its value and delay time was used to divide rats into three groups. Animals selecting the valuable but delayed reinforcement in more than 70% of cases were assigned to the self-controlled groups, while those making this choice in fewer than 30% of case were assigned to the impulsive group and rats showing no preference in choosing reinforcement were members of the ambivalent group. The levels of orientational-exploratory activity and anxiety in rats with different types of behavior were then assessed in an elevated plus maze, on acquisition of a conditioned fear reaction (fear conditioning), and in a neophagophobia test (novelty suppressed feeding). The animals which were least active and most anxious in all tests were those of the self-controlled group. Ambivalent rats were the least anxious in the elevated plus maze test and produced the greatest number of successful trials in terms of finding and eating food in the novel context, as compared with rats of the other groups. Impulsive animals demonstrated more marked freezing reactions on acquisition of the conditioned fear reaction in the fear conditioning test and found food more quickly in the novel context.
Keywordsimpulsivity rats anxiety behavioral study elevated plus maze acquisition of conditioned fear reaction feeding behavior in a novel context
Unable to display preview. Download preview PDF.
- 1.M. I. Zaichenko, G. L. Vanetsian, and G. Kh. Merzhanova, “Differences in the behavior of impulsive and self-controlled rats in the open field and light–dark chamber tests,” Zh. Vyssh. Nerv. Deyat., 61, No. 3, 340–350 (2011).Google Scholar
- 2.M. I. Zaichenko and G. Kh. Merzhanova, “Effects of blockade of D1/D2 dopamine receptors on the behavior of rats with different levels of impulsivity and self-control,” Zh. Vyssh. Nerv. Deyat., 61, No. 5, 1–10 (2011).Google Scholar
- 3.M. I. Zaichenko, G. Kh. Merzhanova, and A. V. Demina, “Studies of the behavior of impulsive’ and ‘self-controlled’ animals using the ‘emotional resonance’ test,” Zh. Vyssh. Nerv. Deyat., 60, No. 2, 192–200 (2010).Google Scholar
- 4.A. V. Kaluev, Stress, Anxiety, and Behavior (current problems in modeling anxious behavior in animals), CSK, Kiev (1998).Google Scholar
- 10.J. A. Gray, “A critique of Eysenck’s theory of personality,” in: A Model for personality, J. J. Eysenck (ed.), Berlin (1981), pp. 246–277.Google Scholar
- 14.E. Hollander and J. Rosen, “Impulsivity,” J. Psychopharmacol., 14, Supplement 1, 39–44 (2000).Google Scholar
- 23.R. J. Rodgers and J. C. Cole, “The elevated plus-maze: pharmacology, methodology and ethology,” in: Ethology and Pharmacology, S. J. Cooper and C. A. Hendrie (eds.) John Willey and Sons, Chichester (1994), pp. 9–44.Google Scholar
- 24.R. J. Rodgers, J. C. Cole, K. Aboualfa, and L. H. Stephenson, “Ethopharmacological analysis of the effects of putative ‘anxiogenic’ agents in the mouse elevated plus maze,” Pharmacol. Biochem. Behav., 52, No. 3, 1–9 (1995).Google Scholar
- 27.K. Ueno, H. Tagashi, and M. Yoshioka, “Behavioral and pharmacological studies of juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deficit/hyperactivity disorder,” Nihon Shinkei Sqaishin Yakurigaku Zasshi, 23, No. 1, 47–55 (2003).Google Scholar