Neuroscience and Behavioral Physiology

, Volume 44, Issue 3, pp 315–319 | Cite as

Valdoxan (agomelatine) in the Treatment of Depression in Cerebrovascular Diseases (results of the Russian Resonance multicenter naturalistic study)

  • N. V. Pizova

The therapeutic efficacy and tolerance of Valdoxan (agomelatine) in the treatment of mild and moderate depression in cerebrovascular diseases (CVD) in routine neurological practice were evaluated. A total of eight Russian centers took part in the study. The study included 88 patients with CVD (18 men, 70 women) aged 40–65 (mean 55.4 ± 6.5) years. Treatment for six weeks eliminated depressive symptomatology in 81.20% of patients. Patients showed regression of fatigue, improvements in working efficiency, achievement of normal values for the coefficient of mental stability, and improvements in sleep.


depression cerebrovascular diseases Valdoxan agomelatine 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Nervous DiseasesYaroslavl State Medical AcademyYaroslavlRussia

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