Neuroscience and Behavioral Physiology

, Volume 45, Issue 1, pp 9–11 | Cite as

Neuroepithelial Bodies in the Lungs in Rats

  • M. A. Syrtsova
  • E. G. Sukhorukova
  • D. E. Korzhevskii

We report here our studies of neuroepithelial bodies (NEB) in the lungs in healthy Wistar rats (n = 12). Immunocytochemical reactions for synaptophysin identified NEB and similar immunopositive nerve terminals. NEB in the lungs in rats were found to be consistently present elements. In contrast to diffuse neuroendocrine elements, these structures were characterized by grouped cells. Some NEB lacked efferent innervation.


neuroepithelial bodies neuroendocrine cells synaptophysin lungs 


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  1. 1.
    E. V. Evsyukova, “ The neuroendocrine system of the human lungs,” Fiziol. Cheloveka, 32, No. 4, 121–130 (2006).Google Scholar
  2. 2.
    O. V. Kirik, P. A. Voronchikhin, E. I. Chumasov, and D. E. Korzhevskii, “Utilization of a reaction for synaptophysin for detection of neuroepithelial bodies in rat lungs,” in: Babukhinskie Lecture in Orel, Retinoidy Press, No. 32, 70–71 (2011).Google Scholar
  3. 3.
    D. E. Korzhevskii, O. V. Kirik, M. N. Karpenko, et al., Theoretical Basis and Practical Applications of Immunohistochemistry Methods, SpetsLit, St. Petersburg (2012).Google Scholar
  4. 4.
    D. E. Korzhevskii, E. G. Sukhorukova, E. G. Gilerovich, et al., “Advantages and deficiencies of the zinc-ethanol-formaldehyde as a fixative for immunocytochemical studies and confocal laser microscopy,” Morfologiya, 144, No. 2, 81–85 (2013).Google Scholar
  5. 5.
    L. V. Filippova and A. D. Nozdrachev, “Sensory structures of the lungs and airways,” Byull. Sib. Med., 10, No. 3, 100–104 (2011).Google Scholar
  6. 6.
    E. I. Chumasov, E. S. Petrova, and D. E. Korzhevskii, “Immunomorphological analysis of the innervation of chromaffin paraganglia of the arteries and heart in mammals,” Zh. Evolyuts. Biokhim., No. 4, 325–331 (2011).Google Scholar
  7. 7.
    E. I. Chumasov, E. D. Petrova, and D. E. Korzhevskii, “Distribution and structural organization of the nerve apparatus in the rat pancreas,” Morfologiya, 139, No. 3, 51–58 (2011).Google Scholar
  8. 8.
    I. Brouns, F. Oztay, I. Pintelon, et al., “Neurochemical pattern of the complex innervation of neuroepithelial bodies in mouse lungs,” Histochem. Cell Biol., 132, No. 2, 34–42 (2008).Google Scholar
  9. 9.
    I. Brouns, J. Van Genechten, D. W. Scheuermann, et al., “Neuroepithelial bodies: a morphologic substrate for the link between neuronal nitric oxide and sensitivity to airway hypoxia,” J. Comp. Neurol., 449, 343–354 (2002).PubMedCrossRefGoogle Scholar
  10. 10.
    E. Cutz, J. Pan, H. Yegar, et al., “Recent advances and controversies on the role of pulmonary neuroepithelial bodies as airway sensors,” Semin. Cell Dev. Biol., 24, 40–50 (2012).PubMedCrossRefGoogle Scholar
  11. 11.
    F. Feyrter, “Über diffuse endokrine epithelie Organe,” Zbl. Inn. Med., 545, 31–32 (1938).Google Scholar
  12. 12.
    M. J. Hannah, A. F. Schmidt, and W. B. Huttner, “Synaptic vesicle biogenesis,” Annu. Rev. Cell Dev. Biol., 15, 733–798 (1999).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • M. A. Syrtsova
    • 1
  • E. G. Sukhorukova
    • 1
  • D. E. Korzhevskii
    • 1
  1. 1.Laboratory for the Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology, Research Institute of Experimental Medicine, North-West BranchRussian Academy of Medical SciencesSt. PetersburgRussia

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