Advertisement

Neuroscience and Behavioral Physiology

, Volume 43, Issue 9, pp 1132–1137 | Cite as

Mental, Autonomic, and Neurophysiological Impairments in Patients with Obesity and Their Correction Using Transcranial Electrical Stimulation

  • Yu. B. Baryl’nik
  • N. V. Bolotova
  • S. V. Levit
  • Yu. M. Raigorodskii
  • L. A. Cherevashchenko
  • I. A. Cherevashchenko
Article
  • 50 Downloads

A total of 85 patients aged 45–68 years with grade I and II obesity for more than five years with concomitant arterial hypertension and atherosclerosis were observed. Patients were divided into two randomized groups. The study group underwent transcranial electrical stimulation (TES) on the background of standard treatment with antiaggregant vascular agents and low-calorie diet. The control group underwent a placebo TES procedure (with the electrodes disconnected). TES therapy was performed using the fronto-mastoid method with sequential stimulation of the right and left hemispheres at a frequency of 10 Hz; patients received a total of 10–12 daily procedures. Patients’ status was evaluated using a series of psychometric scales; autonomic nervous system status was determined by rhythmocardiography; brain bioelectrical activity (EEG) was also studied; the activity of the lipid peroxidation system was assessed. TES produced improvements in most indicators which were significantly greater than average improvements in the control group. Changes in clinical and laboratory parameters were accompanied by a mean 9.8 % decrease in body mass index.

Keywords

somatoneurology somatopsychiatry obesity;therapy transcranial stimulation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    P. K. Anokhin, Biology and Physiology of Conditioned Reflexes [in Russian], Moscow (1968).Google Scholar
  2. 2.
    R. M. Baevskii, O. I. Kirillov, and S. Z. Kletskin, Mathematical Analysis of Changes in Heart Rhythm during Stress [in Russian], Moscow (1984).Google Scholar
  3. 3.
    D. G. Bessesen and R. Kushner, Overweight and Obesity. Prophylaxis, Diagnosis, and Treatment [in Russian], Binom Press, Moscow (2006).Google Scholar
  4. 4.
    N. R. Borodyuk, Adaptation and Humoral Regulation [in Russian], Moscow (2003).Google Scholar
  5. 5.
    Working Group of the European Society of Cardiology and the North American Stimulation and Electrophysiology Society, “Variability in heart rhythm (measurement standards, physiological interpretations, clinical utilization),” Vestn. Aritmol., No. 11, 53–78 (1999).Google Scholar
  6. 6.
    N. P. Goncharov and G. S. Kolesnikova, Corticosteroids: Metabolism, Mechanism of Action, Clinical Utilization [in Russian], Adaman, Moscow (2002).Google Scholar
  7. 7.
    A. I. Karpishchenko, Medical Laboratory Techniques and Diagnosis. Guidelines [in Russian], Spravochnik, St. Petersburg (1999), Vol. 2, p. 27.Google Scholar
  8. 8.
    G. V. Rzheusskaya,Yu. M. Listopadov, M. V. Bobrova, and A. G. Umrudina, “Use of Cymbalta (duloxetine) in the treatment of anxiousdepressive disorders in patients with cerebral ischemia,” Zh. Nevrol. Psikhiat., 109, No. 2, 26–30 (2009).Google Scholar
  9. 9.
    Z. A. Suslina, S. A. Rumyantseva, M. M. Tanashyan, et al., “Complex energy correction of chronic cerebral ischemia,” Zh. Nevrol. Psikhiat., 111, No. 3, 25–29 (2011).Google Scholar
  10. 10.
    V. P. Dvoretskii (ed.), Transcranial Electrical Stimulation: Collection of Articles [in Russian], St. Petersburg (1998).Google Scholar
  11. 11.
    N. Yu. Filina, N. V. Bolotova, Yu. M. Raigorodskii, and N. V. Nikolaeva, “Transcranial magnetic-electrical stimulation with alternating actions on the cerebral hemispheres in the correction of cerebral impairments in children with type 1 diabetes mellitus,” Zh. Nevrol. Psikhiat., 112, No. 3, 39–43 (2012).Google Scholar
  12. 12.
    A. N. Belova and O. N. Shepetova (eds.), Scales, Tests, and Questionnaires in Medical Rehabilitation [in Russian], Avtodor, Moscow (2002), pp. 205–224.Google Scholar
  13. 13.
    M. F. Folstein, S. F. Folstein, and P. R. McHugh, “Mini-mental state. A practical method of grading the cognitive state of patients for the clinician,” J. Psychiat. Res. No. 12, 189–198 (1975).Google Scholar
  14. 14.
    D. S. Knopman, “Current treatment of mild cognitive impairment and Alzheimer’s disease,” Curr. Neurol. Neurosci. Rep., 6, No. 5, 365–371 (2006).PubMedCrossRefGoogle Scholar
  15. 15.
    K. J. Ressler and C. D. Nemeroff, “Role of serotoninergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders,” Depress. Anx., 12, Suppl. 1, 2–19 (2000).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Yu. B. Baryl’nik
    • 1
  • N. V. Bolotova
    • 1
  • S. V. Levit
    • 1
  • Yu. M. Raigorodskii
    • 1
  • L. A. Cherevashchenko
    • 1
  • I. A. Cherevashchenko
    • 1
  1. 1.Saratov State Medical University; Clinical Hospital No. 2; Trima Company, Saratov; and Pyatigorsk Research Institute of BalneologyPyatigorskRussia

Personalised recommendations