The effects of the physical factors of highland altitudes (3200 m) on the lipid composition of tissues and cell membranes were studied in rats. Adaptation of the animals to highland conditions was accompanied by changes in tissue phospholipid composition. Adaptive phospholipid re-composition was seen in the lungs, brain, liver, and skeletal muscle, and in the microsomal membrane fractions isolated from them, with increases in the quantities of phosphatidylinositol and phosphatidic acid. Adaptation at low temperature (+10°C) led to more significant changes in lipid peroxidation and phospholipid composition in tissues and membranes than adaptation in thermally neutral conditions (+30°C). Modification of tissue and cell membrane lipid composition in rats in highland conditions appeared to increase the body’s adaptive potential – the animals showed a tendency to increases in physical work capacity and resistance to hypoxia.
Similar content being viewed by others
References
N. A. Agadzhanyan, Current Questions in Adaptive, Ecological, and Recuperative Medicine [in Russian], Meditsina, Moscow (2006).
N. A. Agadzhanyan and M. M. Mirrakhimov, Mountains and the Resistance of the Body [in Russian], Nauka, Moscow (1970).
Z. I. Barbashova, Acclimation to Hypoxia and its Physiological Mechanisms [in Russian], USSR Academy of Sciences Press, Moscow (1960).
M. J. Berridge, “Molecular basis of internal communications,” V Mire Nauki, 12, 98–109 (1985).
P. Baker and M. M. Mirrakhimov (eds.), The Biology of High-Altitude Peoples [Russian translation], Mir, Moscow (1981).
E. Meddy (ed.), Biochemical Investigations of Membranes [Russian translation], Mir, Moscow (1979).
A. A. Boldyrev, “Oxidative stress and the brain,” Soros. Obraz. Zh., 7, No. 4, 21–28 (2001).
E. Van Lear and K. Stickney, Hypoxia [Russian translation], Meditsina, Moscow (1967).
L. D. Luk’yanova and Yu. I. Kirova, “Effects of hypoxic preconditioning on free-radical processes in the tissues of rats with different levels of tolerance to hypoxia,” Byull. Eksperim. Biol. Med., 3, 263–268 (2011).
V. I. Medvedev, Human Adaptation [in Russian], Institute of the Human Brain, Russian Academy of Medical Sciences (2003).
F. Z. Meerson, Adaptation, Stress, and Prophylaxis [in Russian], Nauka, Moscow (1981).
L. M. Ovsepyan, K. G. Karagezyan, A. V. Medkumyan, and G. V. Zakharyan, “Interaction of oxidative phosphorylation and lipid peroxidation in the brain mitochondrial fraction in hypoxia,” Biokhimiya, 34, 76–79 (2006).
N. N. Sirotinin, Life at Altitude and Altitude Sickness [in Ukrainian], Academy of Sciences of the URSSR, Kiev (1939).
V. N. Orekhovich (ed.), Current Methods in Biochemistry [in Russian], Meditsina (1977).
S. I. Soroko and G. S. Dzhunusova, “Rearrangement of algorithms for interactions between EEG wave components in humans with different types of brain self-regulation mechanisms on adaptation to highland conditions,” Fiziol. Cheloveka, 28, No. 6, 13–23 (2002).
D. Faller and D. Shilds, Molecular Biology of the Cell [in Russian], Binom (2006).
J. Findlay, and U. Evans, Biological Membranes – A Practical Approach [Russian translation], Mir, Moscow (1990).
D. M. Bailey, S. Taudorf, R. M. Berg, et al., “Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness?” Am. J. Physiol. Regul. Integr. Physiol., 297, No. 5, 1283–1292 (2009).
C. Behn, O. F. Araneda, A. J. Lianos, et al., “Hypoxia-related lipid peroxidation: evidences, implications, and approaches,” Respir. Physiol. Neurobiol., 158, No. 2–3, 143–150 (2007).
G. Celedon, G. Gonzales, C. P. Sotomayor, and C. Behn, “Membrane lipid dysfunction and band 3 protein changes in human erythrocytes due to acute hypobaric hypoxia,” Am. J. Physiol. Cell. Physiol., 275, 1429–1431 (1998).
N. S. Chandel and G. R. Budinger, “The cellular basis for diverse responses to oxygen,” Free Radic. Biol. Med., 42, 165–174 (2007).
T. Fakashi, F. Motohatsu, S. Shum, and K. Masakuni, “Effect of in vivo exposure to hypoxia on muscarinic cholinergic receptor coupled phosphoinositide turnover in the rat brain,” Brain Res., 482, No. 1, 109–121 (1989).
K. Heise, S. Estevez, and M. Puntarolo, “Effect of seasonal and latitudinal cold on oxidative stress parameters and activation of hypoxia inducible factor (HIF-1),” J. Comp. Physiol. Biol., 17, 123–133 (2007).
L. A. Horrocks and G. Y. Sun, “Ethanolamine plasmalogens,” in: Research Methods in Neurochemistry, N. Merrs and R. Rodnight (eds.) (1972), Vol. 1, pp. 223–231.
S. Jackowski and C. O. Rock, “Stimulation of phosphatidylinositol 4,5-bisphosphate phospholipase C activity by phosphatidic acid,” Arch. Biochem. Biophys., 268, No. 2, 516–524 (1989).
V. S. Kamanna, B. V. Bassa, and H. Ganjis, “Bioactive lyso-PL and mesangial cell intracellular signaling pathways,” Histol. Histopathol., 20, 603–613 (2005).
H. Katzir, D. Yeheskely, and G. Eyto, “Role of plasma membrane leaflets in drugs uptake and multidrug resistance,” FEBS J., 277, No. 5, 1234–1244 (2010).
T. Kugimiya, K. Suwa, Y. Inada, et al., “Effects of drug induced reduction in oxyhemoglobin affinity on survival time of mice in severe hypoxic conditions,” Tohoku J. Exp. Med., 144, 315–320 (1984).
B. Lant and K. Storey, “An overview of stress response and hypometabolic strategies in Caenorhabditis elegans: conserved and contrasting signals with the mammalian system,” Int. J. Biol. Sci., 6, 9–50 (2010).
M. H. Lee and R. M. Bell, “Phospholipid functional groups involved in protein kinase C activation, phorbol ester binding and binding to mixed micelles,” J. Biol. Chem., 264, No. 25, 14797–14805 (1989).
T. D. Minyailenko, V. P. Pozharov, and M. M. Seredenko, “Severe hypoxia activates lipid peroxidation in the rat brain,” Chem. Phys. Lipids, 55, 25–28 (1990).
C. Rauch, “On the relationship between drugs, size, cell membrane mechanical properties and high level of multidrug resistance,” Eur. Biophys. J., 38, No. 4, 537–546 (2008).
B. Reynafarje, “Biochemical adaptation to chronic hypoxia of high altitude,” Mol. Physiol., 8, 463–471 (1985).
S. I. Soroko and G. S. Dzhunusova, “Changes in frequency spectrum of bioelectrical activity of cortical and subcortical brain structures in rabbit exposed to experimental and high altitude hypoxia,” in: Thermoregulation and Temperature Adaptation, Minsk (1995), pp. 156–159.
S. Torii, N. Kamura, and Y. Suzuki, “Cyclic AMP represses the hypoxic induction of hypoxia-inducible factors in PC12 cells,” J. Biochem., 146, No. 6, 839–844 (2009).
J. M. Wolf, T. Brummendorf, and F. G. Rathjen, “Membrane interaction by covalently attached phosphatidylinositol,” Biochem. Biophys. Res. Commun., 161, No. 2, 931–938 (1989).
D. Yajima, H. Motani, M. Hayakawa, et al., “The relationship between cell membrane damage and lipid peroxidation under the conditions of hypoxia-reoxygenation: analysis of the mechanism using antioxidants and electron transport inhibitors,” Cell Biochem. Funct., 27, 338–343 (2009).
Y. Yao and F. Qin, “Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor,” PLoS Biology, 7, No. 2, 1371–1380 (2009).
F. Zufall and T. Leinders, “The cellular and molecular basis of adaptation,” Chemical Senses, 35, No. 4, 473–476 (2000).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 98, No. 1, pp. 137–146, January, 2012.
Rights and permissions
About this article
Cite this article
Yakovlev, V.M., Vishnevskii, A.A. & Shanazarov, A.S. Tissue and Cell Membrane Lipid Composition in Rats on Adaptation to Highland Conditions. Neurosci Behav Physi 43, 918–923 (2013). https://doi.org/10.1007/s11055-013-9829-6
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-013-9829-6