Neuroscience and Behavioral Physiology

, Volume 43, Issue 3, pp 336–340 | Cite as

Analysis of the Spatial Distribution of Gap Junctions Relative to Chemical Synapses on Serial Ultrathin Sections of the Rat Barrel Cortex

  • E. Yu. Kirichenko
  • A. G. Sukhov
  • A. K. Logvinov
  • P. E. Povilaitite

Electron microscope studies of gap junctions (GJ) on serial sections of the barrel cortex in rats showed that GJ make contact with one or both of the processes forming chemical synapses, though these associations could not be demonstrated on single sections. On serial sections, a single field could show two GJ close together, and each GJ could be followed through 2–3 sections in the series. Given the variants described for the distribution of GJ in the cortex, it is suggested that GJ may provide the structural basis for local synchronization of bioelectrical activity not only at the postsynaptic, but also at the presynaptic level; formation of GJ occurs both before and after development of chemical synapses.


brain barrel cortex gap junctions serial sections chemical synapses rat 


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  1. 1.
    M. B. Berkinblit and L. M. Chailakhyan, “Electrical synapses,” in: Handbook of Physiology. General Physiology of the Nervous System [in Russian], Nauka, Leningrad (1979), pp. 398–441 (1979).Google Scholar
  2. 2.
    E. Yu. Kirichenko, P. E. Povilaitite, and A. G. Sukhov, “The role of gap junctions in local rhythmogenesis in cortical columns,” Morfologiya, 133, No. 1, 31–34 (2008).Google Scholar
  3. 3.
    A. K. Logvinov, E. Yu. Kirichenko, P. E. Povilaitite, and A. G. Sukhov, “Structural organization of the barrel cortex in rats (an immunocytochemical study),” Morfologiya, 137, No. 1, 10–13 (2010).Google Scholar
  4. 4.
    M. Bani-Yaghoub, T. M. Underhill, and C. C. Naus, “Gap junction blockage interferes with neuronal and astroglial differentiation of mouse P19 embryonal carcinoma cells,” Dev. Genet., 24, 69–81 (1999).PubMedCrossRefGoogle Scholar
  5. 5.
    J. J. Bozzola and L. D. Russell, Electron Microscopy. Principles and Techniques for Biologists, Jones and Bartlett Publishers, Boston (1992).Google Scholar
  6. 6.
    L. A. Elias, D. D. Wang, and A. R. Kriegstein, “Gap junction adhesion is necessary for radial migration in the neocortex,” Nature, 448, 901–907 (2007).PubMedCrossRefGoogle Scholar
  7. 7.
    T. Fukuda and T. Kosaka, “Gap junction linking the dendritic network of GABAergic interneurons in the hippocampus,” J. Neurosci., 20, No. 4, 1519–1528 (2000).PubMedGoogle Scholar
  8. 8.
    R. J. Montoro and R. Yuste, “Gap junctions in developing neocortex: a review,” Brain Res. Rev., No. 47, 216–226 (2004).PubMedCrossRefGoogle Scholar
  9. 9.
    J. C. de Rivero Vaccari, R. A. Corriveau, and A. B. Belousov, “Gap junctions are required for NMDA receptor-dependent cell death in developing neurons,” J. Neurophysiol., 98, 2878–2886 (2007).PubMedCrossRefGoogle Scholar
  10. 10.
    D. Schmitz, S. Schuchmann, A. Fisahn, et al., “Axo-axonal coupling: a novel mechanism for ultrafast neuronal communication,” Neuron, 31, 831–840 (2001).PubMedCrossRefGoogle Scholar
  11. 11.
    B. Sutor and T. Hagerty, “Involvement of gap junctions in the development of the neocortex,” Biochem. Biophys. Acta, 1719, 59–68 (2005).PubMedCrossRefGoogle Scholar
  12. 12.
    K. L. Todd, W. B. Kristan, and K. A. French, “Gap junction expression is required for normal chemical synapse formation,” J. Neurosci., 30, No. 45, 15277–15285 (2010).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • E. Yu. Kirichenko
    • 1
  • A. G. Sukhov
    • 1
  • A. K. Logvinov
    • 1
  • P. E. Povilaitite
    • 2
  1. 1.Department of Neural Networks (Director: Doctor of Biological Sciences A. G. Sukhov), A. B. Kogan Research Institute of NeurocyberneticsSouthern Federal UniversityRostov OblastRussia
  2. 2.Department of Experimental Pathomorphology and Electron Microscopy (Director: Master of Biological Sciences P. E. Povilaitite)Rostov Regional State Company “Pathological Anatomy Bureau,”Rostov-on-DonRussia

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