Neuroscience and Behavioral Physiology

, Volume 42, Issue 8, pp 876–879 | Cite as

Genetic Risk Factors for Multiple Sclerosis in the Population of the Altai District

  • I. V. Smagina
  • S. A. Elchaninova
  • A. G. Zolovkina
  • Yu. N. Ignatova
  • E. A. Kudryavtseva

A case-control study in the Russian population of the Altai District showed that increased risk of multiple sclerosis was associated with DR15 and DR3 and the combination of the female gender and the A allele of the rs1800629 TNFα gene. There was no association between the occurrence of this disease and polymorphism of the CD40 gene (rs60764022).


multiple sclerosis DRB1 gene tumor necrosis factor alpha (TNFα) gene CD40 gene 


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • I. V. Smagina
    • 1
    • 2
  • S. A. Elchaninova
    • 3
  • A. G. Zolovkina
    • 3
  • Yu. N. Ignatova
    • 1
  • E. A. Kudryavtseva
    • 4
  1. 1.Department of Neurology, District Clinical HospitalBarnaulRussia
  2. 2.Department of Nervous Diseases with Neurology and Reflexotherapy, Faculty of Higher Qualification and Professional Specialist TrainingAltai State Medical UniversityBarnaulRussia
  3. 3.Department of Biochemistry and Clinical Laboratory DiagnosticsAltai State Medical UniversityBarnaulRussia
  4. 4.Novosibirsk State UniversityNovosibirskRussia

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