Genetic Risk Factors for Multiple Sclerosis in the Population of the Altai District
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A case-control study in the Russian population of the Altai District showed that increased risk of multiple sclerosis was associated with DR15 and DR3 and the combination of the female gender and the A allele of the rs1800629 TNFα gene. There was no association between the occurrence of this disease and polymorphism of the CD40 gene (rs60764022).
Keywordsmultiple sclerosis DRB1 gene tumor necrosis factor alpha (TNFα) gene CD40 gene
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- 1.A. N. Boiko and O. O. Favorova, “Multiple sclerosis: molecular and cellular mechanisms,” Mol. Biol., 29, No. 4, 727–749 (1995).Google Scholar
- 2.I. V. Smagina, Yu. N. Lichenko, A. S. Fedyanin, and S. A. Elchaninova, “Epidemiology of multiple sclerosis in the Altai district,” Nevrol. Zh., No. 1, 24–27 (2010).Google Scholar
- 4.T. E. Shmidt and N. N. Yakhno, Multiple Sclerosis: Guidelines for Doctors [in Russian], MEDpress Inform, Moscow, 2nd Edition (2010).Google Scholar
- 9.O. O. Favorova, A. V. Favorov, A. N. Boiko, et al., “Three allele combinations associated with multiple sclerosis,” BMC Med. Genetics, 63, 1–9 (2006).Google Scholar
- 11.J. F. Kurtzke, “Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS),” Neurol., 33, No. 12, 1444–1452 (1983).Google Scholar
- 16.K. Selmaj, C. Raine, B. Cannella, et al., “Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions,” J. Clin. Invest., 37, 949–954 (1997).Google Scholar