Selective Effects of Dehydroepiandrosterone Sulfate on Corticoliberin-Induced Anxiety
The effects of dehydroepiandrosterone sulfate (DHEA-S) on changes in the levels of anxiety induced by administration of the stress neurohormone corticoliberin were studied. A T maze was used to select Wistar rats with active and passive strategies of adaptive behavior. Testing of the active group in an elevated plus maze was used to select low- and high-anxiety individuals. Intranasal administration of corticoliberin to low-anxiety active rats resulted in decreases in total activity and increases in the level of anxiety, while high-anxiety animals had low sensitivity to this neurohormone. Prior administration of DHEA-S at a dose of 3 mg/100 g had antistress effects in low-anxiety rats and anxiolytic effects in high-anxiety rats. In passive animals, which were characterized by initially high levels of anxiety and were resistant to corticoliberin, administration of DHEA-S also had antistress actions. These results led to the conclusion that the effects of DHEA-S depended on the initial psychoemotional state and behavioral sensitivity to corticoliberin.
Keywordscorticoliberin dehydroepiandrosterone sulfate anxiety rats behavior
Unable to display preview. Download preview PDF.
- 1.N. P. Goncharov, G. V. Katsiya, and A. N. Nizhnik, Dehydroepiandrosterone: Properties, Metabolism, and Biological Significance [in Russian], Adamant, Moscow (2004).Google Scholar
- 2.T. A. Obut, Androgens and the Adaptation of the Body: the Biological Significance of Adrenocortical Androgens [in Russian], Art-Avenue, Novosibirsk (2004).Google Scholar
- 3.T. A. Obut, T. V. Lipina, L. A. Koryakina, and N. N. Kudryavtseva, “Is dehydroepiandrosterone an anxiolytic agent?” Zh. Vyssh. Nerv. Deyat., 51, No. 4, 502–509 (2001).Google Scholar
- 4.O. G. Semenova, M. G. Semenova, V. V. Rakitskaya, and V. G. Shalyapina, “Psychomotor reactivity to corticoliberin in rats with active and passive strategies of adaptive behavior in a water immersion model of depression,” Ros. Fiziol. Zh. im. I. M. Sechenova, 92, No. 8, 1016–1021 (2006).Google Scholar
- 5.V. G. Shalyapina, “Corticoliberin in the regulation of adaptive behavior and the pathogenesis of post-stress psychopathology,” in: Basic Neuroendocrinology [in Russian], Elbi-SPb, St. Petersburg (2005), pp. 84–146.Google Scholar
- 6.V. G. Shalyapina, U. A. Vershinina,V. V. Rakitskaya, L. Yu. Ryzhova, M. G. Semenova, and O. G. Semenova, “Changes in the adaptive behavior of active and passive Wistar rats in an aqueous immersion model of depression,” Zh. Vyssh. Nerv. Deyat., 56, No. 4, 543–547 (2006).Google Scholar
- 7.V. G. Shalyapina, V. V. Rakitskaya, and E. A. Rybnikova, “Corticotropin-releasing hormone in the integration of endocrine functions and behavior,” Usp. Fiziol. Nauk., 34, No. 4, 75–92 (2003).Google Scholar
- 8.V. G. Shalyapina, V. V. Rakitskaya, M. G. Semenova, and O. G. Semenova, “The hormonal function of the hypophyseal-adrenocortical system in the pathogenetic heterogeneity of post-stress depression,” Ros. Fiziol. Zh. im. I. M. Sechenova, 92, No. 4, 480–487 (2006).Google Scholar
- 24.R. Rupprecht, Neuroactive Steroids. Handbook of Stress and the Brain, T. Steckler, N. H. Kalin, and J. M. Reul (eds.) (2005),Vol. 15, pp. 545–560.Google Scholar
- 27.O. M. Wolkowitz, V. I. Reus, and E. Roberts, “Role of DHEA and DHEA-S in Alzheimer’s disease: replay,” Am. J. Psychiatry, 150, No. 9, 1433 (1993).Google Scholar