Neuroscience and Behavioral Physiology

, Volume 42, Issue 2, pp 205–209 | Cite as

Structure of Mesenteric Lymph Nodes in Healthy Neonatal Rats and Rats Subjected to Prenatal Exposure to Ethanol

  • P. V. Pugach

The aim of the present work was to study the topography and structure of cranial mesenteric lymph nodes in neonatal rats developing after prenatal exposure to ethanol. Females received 15% ethanol for 1, 2, 3, 4, 5, or 6 months before establishment of pregnancy and on throughout pregnancy. Morphometric and classical histological methods were used. The number of lymph nodes and their areas on sections in neonatal rats varied depending on the duration of pregravid exposure of females to ethanol. The lowest values of these measures were seen in rats born to females exposed to alcohol for three months. Increases in the duration of ethanol exposure led to increases in the number and cross-sectional area of lymph nodes. The largest number of lymph nodes was seen in rats born to females exposed to ethanol for four months, while the maximum area was seen in rats born to females exposed to ethanol for six months.


lymph nodes ethanol pregnancy 


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  1. 1.
    L. S. Bespalova, “Comparative anatomical studies of lymph nodes of the abdominal cavity of mammals and their significance in studies of the evolution of the human lymphoid system” in: The Morphogenesis of the Vascular and Nervous Systems [in Russian], Zdorovie, Kiev (1967), pp. 19–33.Google Scholar
  2. 2.
    Yu. I. Borodin, M. R. Sapin, L. E. Etingen, et al., Functional Anatomy of the Lymph Node [in Russian], Nauka, Novosibirsk (1992).Google Scholar
  3. 3.
    E. N. Zharikova, The Peripheral Organs of the Immune System (development, structure, function) [in Russian], Minsk, Belarus (1979).Google Scholar
  4. 4.
    I. M. Iosifov, “The lymphatic system of the brown rat,” Trudy Erevan. Zoovet. Inst., No. 8, 227–255 (1944).Google Scholar
  5. 5.
    A Strategy for the Implementation of State Policy in Relation to Decreasing the Scale of Alcohol Consumption by Production and Prevention of Alcoholism in the Population of the Russian Federation to 2002, [in Russian], Approved by order of the Government of the Russian Federation, December 20, 2009, No. 2128-r.Google Scholar
  6. 6.
    D. A. Medvedev, “Meeting presentation: Measures to reduce alcohol consumption in Russian,” Ross. Gazeta, No. 4973, August 13, 2009, p. 1.Google Scholar
  7. 7.
    E. A. Nadyrov, Postnatal Development and the Reactivity of the Thymus in the Offspring of Rats Alcoholized during Pregnancy: Author’s Abstract of Doctoral Thesis in Medical Sciences [in Russian], Moscow (1991).Google Scholar
  8. 8.
    P. V. Pugach, N. R. Karelina, S. V. Kruglov, and S. V. Svirin, “Characteristics of thymic structure and lymph nodes in neonatal rats after prenatal exposure to alcohol,” in: Current Problems in Morphology [in Russian], VNOAGE, Kirov Military Medical Academy, St. Petersburg (2008), pp. 125–128.Google Scholar
  9. 9.
    Ya. A. Rakhimov, The Thoracic Duct in Mammals [in Russian], Irfon, Dushanbe (1968).Google Scholar
  10. 10.
    T. N. Savitskaya, Structure of the Tracheobronchial and Mesenteric Lymph Nodes during the Antenatal and Postnatal Periods of Ontogeny (an anatomical experimental study): Author’s Abstract of Doctoral Thesis in Medical Sciences, [in Russian], Yaroslavl (1985).Google Scholar
  11. 11.
    A. A. Sushko and L. V. Chernyshenko, Characteristics of the Functional Anatomy of the Lymphatic System [in Russian], Zdorovie, Kiev (1966).Google Scholar
  12. 12.
    V. A. Tabolin, S. A. Zhdanova, I. N. Pyatnitskaya, and G. A. Uryvchikov, Alcohol and Offspring [in Russian], Vyssh. Shkola, Moscow (1988).Google Scholar
  13. 13.
    L. V. Timoshenko, N. P. Skakun, and G. K. Skakun, Fetal Alcohol Syndrome [in Russian], Zdorove, Kiev (1987).Google Scholar
  14. 14.
    V. E. Torbek, “Micro- and ultrastructure of the thymus in the offspring of rats subjected to alcoholization,” Arkh. Anat., 100, No. 6, 61–65 (1999).Google Scholar
  15. 15.
    V. E. Torbek, “Morphofunctional state of reticuloepithelial cells of the thymus in the offspring of alcoholized rats,” Morfologiya, 137, No. 4, 91 (2010).Google Scholar
  16. 16.
    Z. S. Khlystova, Establishment of the Human Fetal Immunogenesis System [in Russian], Meditsina, Moscow (1987).Google Scholar
  17. 17.
    V. E. Shurkus, E. A. Shurkus, and L. D. Roman, Genesis, Topography, and Connections of Lymph-Conducting Pathways of the Abdominal Cavity (theoretical and applied aspects) [in Russian], Leningrad Regional Oncological Clinic Press, St. Petersburg (2002).Google Scholar
  18. 18.
    S. G. Evrard, “Diagnostic criteria for fetal alcohol syndrome and fetal alcohol spectrum disorders,” Arch. Argent. Pediatr., 108, No. 1, 61–70 (2010).PubMedGoogle Scholar
  19. 19.
    J. McGill, D. K. Meyrholz, M. Edsen-Moore, et al., “Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections,” J. Immunol., 182, No. 12, 7803–7808 (2009).PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  1. 1.Department of Human Anatomy (Director: Professor N. R. Karelina)St. Petersburg Sate Pediatric Medical AcademySt. PetersburgRussia

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