Contribution of Glucocorticoid Hormones to the Gastroprotective Effect of Ischemic Preconditioning in Rats in Normal Conditions and In Prostaglandin Deficiency
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The aim of the present work was to study the contribution of glucocorticoid hormones to the gastroprotective effects of ischemic preconditioning in a gastric ischemia/reperfusion model in rats with normal and deficient prostaglandin production. The contribution of glucocorticoids was evaluated by adrenalectomy followed by corticosterone replacement therapy and transient inhibition of corticosterone synthesis with metyrapone. Prostaglandin synthesis was blocked with indomethacin. Gastric ischemia was created by compression of the celiac artery in anesthetized rats. Ischemic preconditioning (0.5 h ischemia/reperfusion) stimulated corticosterone production and decreased the formation of gastric erosions due to 3.5 h ischemia/reperfusion. Adrenalectomy and administration of metyrapone prevented the gastroprotective effect of ischemic preconditioning on the backgrounds of both normal and deficient prostaglandin production. Corticosterone replacement therapy restored the effect of ischemic preconditioning in adrenalectomized rats, even in conditions of blockade of prostaglandin synthesis. Thus, glucocorticoid hormones make a contribution to the gastroprotective effect of ischemic preconditioning in conditions of normal prostaglandin production, as well as in conditions of blockade of prostaglandin synthesis.
Keywordsischemic preconditioning ischemia/reperfusion stomach erosions glucocorticoid hormones gastroprotection rats
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