Neuroscience and Behavioral Physiology

, Volume 42, Issue 1, pp 63–66 | Cite as

Development of the Ordered Organization of Corticocortical Connections between Field 17 and the Posteromedial Wall of the Lateral Suprasylvian Sulcus in Early Postnatal Ontogeny in Cats


The development of the clustered organization of corticocortical connections between visual field 17 and the posteromedial wall of the lateral suprasylvian sulcus (field PMLS) was studied in cats. The retrograde axonal marker horseradish peroxidase was microinjected into the PMLS region. The distribution of labeled initial neurons was analyzed in field 17 in kittens aged five and 12 weeks. A significant increase in the area of cortex containing labeled neurons and a decrease in their distribution density were seen between week 5 and week 12. Analysis of Fourier amplitude and phase spectra demonstrated differences in the distributions of labeled neurons in kittens of different ages and provided evidence of the incomplete formation of the clustered organization of connections in these animals. The temporal morphofunctional characteristics of the development of intercortical connections of the PMLS zone as compared with other visual areas of the cortex are discussed.


corticocortical connections field 17 posteromedial wall of the lateral suprasylvian sulcus cats early ontogeny 


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  1. 1.
    F. N. Makarov, V. A. Lyakhovetskii, and L. A. Markova, “Ordered structural organization of intrahemisphere connections in the cat visual cortex,” Morfologiya, 124, No. 4, 24–28 (2003).Google Scholar
  2. 2.
    S. N. Merkulieva and F. N. Makarov, “Ontogenetic characteristics of the organization of corticocortical connections in the primary visual cortex and lateral suprasylvian area of the brain in cats,” Ros. Fiziol. Zh. im. I. M. Sechenova, 96, No. 3, 271–279 (2010).Google Scholar
  3. 3.
    N. S. Merkulieva and N. I. Nikitina, “Method for detecting and quantifying two-dimensional patterns of the distribution of labeled neurons in the cerebral cortex,” Morfologiya, 138, No. 5, 55–58 (2010).Google Scholar
  4. 4.
    J. D. Boyd and J. A. Matsubara, “Projections from V1 to lateral suprasylvian cortex: an efferent pathway in the cat’s visual cortex that originates preferentially from CO blob columns,” Vis. Neurosci., 16, 849–860 (1999).PubMedCrossRefGoogle Scholar
  5. 5.
    E. M. Callaway and L. C. Katz, “Effects of binocular deprivation on the development of clustered horizontal connections in cat striate cortex,” Proc. Natl. Acad. Sci. USA, 88, 745–749 (1991).PubMedCrossRefGoogle Scholar
  6. 6.
    B. Conway, J. D. Boyd, T. H. Stewart, and J. Matsubara, “The projection from V1 to extrastriate area 21a: a second patchy efferent pathway that colocalizes with CO blob columns in cat visual cortex,” Cereb. Cortex, 10, 149–159 (2000).PubMedCrossRefGoogle Scholar
  7. 7.
    N. W. Daw, Visual Development, Springer, New York (2006).Google Scholar
  8. 8.
    B. M. Hooks and C. Chen, “Distinct roles for spontaneous and visual activity in remodeling of the retinogeniculate synapse,” Neuron, 52, 281–291 (2006).PubMedCrossRefGoogle Scholar
  9. 9.
    G. M. Innocenti and R. Caminiti, “Postnatal shaping of callosal connections from sensory areas,” Exp. Brain Res., 38, 381–394 (1980).PubMedCrossRefGoogle Scholar
  10. 10.
    G. M. Innocenti and D. J. Price, “Exuberance in the development of cortical networks,” Nat. Rev. Neurosci., 6, 955–965 (2005).PubMedCrossRefGoogle Scholar
  11. 11.
    M.-M. Mesulam, “Tetramethylbenzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents,” J. Histochem. Cytochem., 26, 106–117 (1978).PubMedCrossRefGoogle Scholar
  12. 12.
    V. B. Mountcastle, “Modality and topographic properties of single neurons of cat’s somatic sensory cortex,” J. Neurophysiol., 20, 408–434 (1957).PubMedGoogle Scholar
  13. 13.
    J. Szentagothai, “The module-concept of cerebral cortex architecture,” Brain Res., 95, 475–496 (1975).PubMedCrossRefGoogle Scholar
  14. 14.
    J. T. Trachtenberg and M. P. Stryker, “Rapid anatomical plasticity of horizontal connections in the developing visual cortex,” J. Neurosci., 21, No. 10, 3476–3482 (2001).PubMedGoogle Scholar
  15. 15.
    J. R. Villablanca and C. E. Olmstead, “Neurological development of kittens,” Dev. Psychobiol., 12, No. 2, 101–127 (1979).PubMedCrossRefGoogle Scholar
  16. 16.
    T. N. Wiesel and D. H. Hubel, “Effects of visual deprivation on morphology and physiology of cells in the cat’s lateral geniculate body,” J. Neurosci., 26, No. 6, 978–993 (1963).Google Scholar
  17. 17.
    T. J. Zumbroich and C. Blakemore, “Spatial and temporal selectivity in the suprasylvian visual cortex of the cat,” J. Neurosci., 7, 482–500 (1987).PubMedGoogle Scholar
  18. 18.
    T. J. Zumbroich, D. J. Price, and C. Blakemore, “Development of spatial and temporal selectivity in the suprasylvian visual cortex of the cat,” J. Neurosci., 8, 2713–2728 (1988).PubMedGoogle Scholar

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© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  1. 1.Neuromorphology Laboratory (Director Professor F. N. Makarov), I. P. Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia

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