Effects of an Agonist and an Antagonist of 5-HT1A Serotonin Receptors on Learning in Female Rats during the Ovarian Cycle
- 42 Downloads
The experiments reported here addressed comparative analysis of the role of 5-HT1A serotonin receptors in the mechanisms mediating cognitive processes during natural cyclical changes in sex hormone levels in adult female rats. The effects of chronic (14 days) administration of the 5-HT1A serotonin receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and the 5-HT1A serotonin receptor antagonist NAN-190 (0.1 mg/kg, i.p.) to females at different phases of the ovarian cycle on conditioned reflex responses were studied. A conditioned passive avoidance reaction and the Morris water maze were used as behavioral tests. Chronic administration of NAN-190 to females led to the appearance of the conditioned passive avoidance response in the proestrus and estrus phases, in contrast to control females, but had no effects on the dynamics of spatial learning in the Morris water test. Chronic administration of 8-OH-DPAT consistently impaired the processes of non-spatial and spatial learning in females regardless of the phase of the ovarian cycle. The results obtained in these experiments evidenced the modulatory role of 5-HT1A serotonin receptors in learning processes in rats in key phases of the ovarian cycle.
Keywords8-OH-DPAT NAN-190 5-HT1A serotonin receptors learning ovarian cycle female rats
Unable to display preview. Download preview PDF.
- 1.Ya. Buresh, O. Bureshova, and J. P. Houston, Methods and Basic Experiments for Studies of the Brain and Behavior [in Russian], Vysshaya Shkola, Moscow (1991).Google Scholar
- 2.Ya. D. Kirshenblat, Handbook in Endocrinology [in Russian], Vysshaya Shkola, Moscow (1969).Google Scholar
- 3.D. B. Ponomarev and E. P. Vinogradova, “Comparative analysis of learning ability in the Morris water maze in rats with different rates of acquisition of an active avoidance conditioned reflex,” Zh. Vyssh. Nerv. Deyat., 50, No. 6, 974–981 (2000).Google Scholar
- 4.N. S. Sapronov and Yu. O. Fedotova, Hormones of the Hypothalamo-Hypophyseal-Ovarian System and the Brain [in Russian], Formizdat, St. Petersburg (2009).Google Scholar
- 14.D. R. Rubinow and P. J. Schmidt, “Menstrual cycle-related and perimenopausal-related affective disorders,” in: Psychoneuroendocrinology. The Scientific Basis of Clinical Practice, O. Wolkowitz and A. Rothschild (eds.), Am. Psychiatr. Publ. Inc., Washington, London (2003), pp. 245–280.Google Scholar
- 15.L. A. Rybaczyk, M. J. Bashaw, D. R. Pathak, S. M. Moody, R. M. Gilders, and D. L. Holzschu, “An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology,” Biomed Central Women’s Health, 5, 5–12 (2005).Google Scholar
- 19.T. M. Souza, C. Rodrigues, M. M. Souza, E. Vinade, A. Coitinho, H. Choi, and I. Izquierdo, “Involvement of the serotonergic types 1A (5-HT1A) receptor in the agranular insular cortex in the consolidation of memory for inhibitory avoidance in rats,” Behav. Pharmacol., 12, 349–353 (2001).PubMedCrossRefGoogle Scholar
- 21.S. Wissnik, B. van der Burg, B. S. Katzenellbogen, and P. T. van der Saag, “Synergic activation of the serotonin-1A receptor by nuclear factor-κB and estrogen,” Mol. Endocrinol., 15, 542–552 (2001).Google Scholar