Neuroscience and Behavioral Physiology

, Volume 38, Issue 4, pp 355–357 | Cite as

Neuron density in the hippocampus in rat strains with contrasting nervous system excitability after prolonged emotional-pain stress

  • N. V. Shiryaeva
  • V. V. Vshivtseva
  • N. A. Mal’tsev
  • V. N. Sukhorukov
  • A. I. Vaido


A model system consisting of two rat strains bred for nervous system excitability in response to electric shocks was used to study changes in the number density of neurons in hippocampal field CA3 at 24 h, two weeks, and two and six months after prolonged emotional-pain stress (PEPS). Neuron density in hippocampal field CA3 decreased after completion of PEPS. These changes arose at different time points in the different rat strains (one day for low-excitability rats, two months for high-excitability rats) and persisted to six months. Thus, this is the first demonstration that persistent differential effects of stress on the number density of neurons in hippocampal field CA3, which plays an important role in learning and memory processes, depend on genetically determined constitutive characteristics of the nervous system.

Key words

excitability hippocampus neuron emotional-pain stress rats 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    A. I. Vaido, Physiological-Genetic Analysis of Nervous System Excitability and Behavior in Laboratory Rats [in Russian], Author’s Abstract of Doctoral Thesis in Biological Sciences, St. Petersburg (2000).Google Scholar
  2. 2.
    N. V. Shiryaeva, A. I. Vaido, and N. G. Lopatina, “Long-delayed effects of neuroticization on behavior in rats differing in terms of nervous system excitability,” Zh. Vyssh. Nerv. Deyat., 46, No. 1, 157–162 (1996).Google Scholar
  3. 3.
    R. D. Alarcon, C. G. Glover, and C. G. Deering, “The cascade model: an alternative to comorbidity. I. The pathogenesis of posttraumatic stress disorder,” Psychiatry, 62, No. 2, 114–125 (1999).PubMedGoogle Scholar
  4. 4.
    J. D. Bremner, “Neuroimaging of posttraumatic stress disorder,” Psych. Annals, 28, No. 8, 445–446 (1998).Google Scholar
  5. 5.
    J. D. Bremner, “Hypotheses and controversies related to effects of stress on hippocampus: an argument for stress-induced damage of the hippocampus in patient with posttraumatic stress disorder,” Hippocampus, 11, 121–124 (2001).CrossRefGoogle Scholar
  6. 6.
    K. Hecht, K. Treptov, K. Choinovski, and M. Peschel, Die Raumzeitliche Organization der Reiz-Reaktion-Beziehungen Bedingtreflectorischer Prozesse, Fischer, Jena (1972).Google Scholar
  7. 7.
    B. S. McEwen and A. M. Magarinos, “Stress effects on morphology and function of the hippocampus,” Ann. N.Y. Acad. Sci., 21, No. 821, 271–274 (1997).CrossRefGoogle Scholar
  8. 8.
    A. C. McFarlane, “Traumatic stress in the 21st century,” Aust. N.Z. J. Psychiatry, 34, No. 6, 896–902 (2000).PubMedCrossRefGoogle Scholar
  9. 9.
    A. C. McFarlane, R. Yehuda, and C. R. Clark, “Biologic models of traumatic memories and post-traumatic stress disorder. The role of neural networks,” Psychiatr. Clin. Amer., 25, 253–270 (2002).CrossRefGoogle Scholar
  10. 10.
    K. Mizoguchi, T. Kanishita, D. H. Chui, and T. Tabira, “Stress induces neuronal death in the hippocampus of rats,” Neurosci. Lett., 138, No. 1, 157–160 (1992).PubMedCrossRefGoogle Scholar
  11. 11.
    R. M. Sapolsky, “Atrophy of hippocampus in posttraumatic stress disorder: how and when,” Hippocampus, No. 11, 90–91 (2001).Google Scholar
  12. 12.
    G. K. Volmann-Honsdorf, G. Flugge, and E. Fuchs, “Chronic psychosocial stress does not affect the number of pyramidal neurons in tree shrew hippocampus,” Neurosci. Lett., 233, No. 2–3, 121–124 (1997).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • N. V. Shiryaeva
    • 1
  • V. V. Vshivtseva
    • 2
  • N. A. Mal’tsev
    • 3
  • V. N. Sukhorukov
    • 1
  • A. I. Vaido
    • 1
  1. 1.Laboratory for the Genetics of Higher Nervous Activity (Director: Doctor of Biological Sciences A. I. Vaido)Russia
  2. 2.Laboratory for the Regulation of Brain Neuron Function (Director: Professor M. O. Samoilov)Russia
  3. 3.Science-Research Cinematography Group (Director: Doctor of Technical Sciences Yu. I. Levkovich), I. P. Pavlov Institute of PhysiologyRussian Academy of SciencesSt. Petersburg

Personalised recommendations