Functional roles of the monoaminergic and aminoacidergic mechanisms of the dorsal pallidum in anxiety of different aversive origins
- 49 Downloads
Microinjections of serotonin and glutamic acid into the globus pallidus in conditions of free selection between a light and a dark chamber showed these substances to have antiaversive activity in rats in the “threatening situation” test but not in the “illuminated area” test. Local administration of dopamine and GABA into this basal ganglia formation had no effect on the mechanisms of voluntary movement but countered anxiety states in both behavioral models. These results provide evidence that the neurotransmitter systems of the dorsal pallidum have different degrees of involvement in the operative control of behavior when the modality of the aversive stimulus changes.
Key wordsglobus pallidus anxiety of different aversive origins neurochemical mechanisms
Unable to display preview. Download preview PDF.
- 1.A. A. Garibyan and L. S. Gambaryan, “Involvement of the basal ganglia in the mechanisms of afferent synthesis and decision-taking,” Usp. Fiziol. Nauk., 16, No. 2, 112–128 (1985).Google Scholar
- 2.N. F. Suvorov and V. T. Shuvaev, “Involvement of the basal ganglia in the organization of behavior,” Ros. Fiziol. Zh., 88, No. 10, 1233–1240 (2002).Google Scholar
- 3.A. N. Talalaenko, G. K. Krivobok, Yu. V. Babii, B. A. Bogdanov, and N. N. Perch, “Neurochemical mechanisms of the central nucleus of the amygdaloid complex and the anxiolytic action of tranquillizers in different models of anxiety states,” Zh. Vyssh. Nerv. Deyat., 44, No. 6, 1116–1123 (1994).Google Scholar
- 4.A. N. Talalaenko, D. V. Pankrat’ev, and N. V. Goncharenko, “Neurochemical characteristics of the ventromedial hypothalamus in execution of the antiaversive effects of anxiolytics in different models of anxiety,” Ros. Fiziol. Zh., 87, No. 9, 1217–1226 (2001).Google Scholar
- 5.A. F. Yakimovskii, “Execution of a conditioned avoidance reflex in conditions of repeated activation of the dopaminergic system of the globus pallidus,” Zh. Vyssh. Nerv. Deyat., 48, No. 1, 47–53 (1998).Google Scholar
- 6.A. F. Yakimovskii, “Analysis of striopallidal interactions in the control of avoidance behavior,” Ros. Fiziol. Zh., 87, No. 1, 77–83 (2001).Google Scholar
- 10.P. Löschmann, F. Eblen, U. Wöllner, T. Klockgether, and L. Turski, “Behavioural role of glutamate in the basal ganglia,” Behav. Pharmacol., 5,Suppl. 1, 12 (1994).Google Scholar