Neuroscience and Behavioral Physiology

, Volume 37, Issue 1, pp 19–26 | Cite as

Effects of rapid and slow cooling on thermoregulatory reactions in hypertensive rats after administration of calcium

  • T. V. Kozyreva
  • S. V. Lomakina
  • E. Ya. Tkachenko
  • A. L. Markel’


Iontophoretic administration of calcium ions into the skin close to the application site of a cold stimulus decreased the threshold of thermoregulatory reactions in hypertensive rats to a greater extent than in normotensive control animals, which may be evidence that the tissues involved in thermoregulatory reactions to cold have a greater sensitivity to calcium in hypertensive rats. The initially earlier onset of vascular and metabolic reactions and the increase in the vascular reaction seen in hypertensive rats became more marked after administration of calcium. Treatment with calcium, increasing the vascular reaction to cooling, facilitates a more marked discrimination between hyper-and normotensive animals in terms of the appearance of the vasoconstrictor reactions of skin blood vessels in response to cold. The effects of the added calcium on cold-dependent reactions depended on the rate of cooling.

Key words

thermoregulatory reactions cooling arterial hypertension calcium ions 


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  1. 1.
    A. R. Antonov, V. V. Letyagina, A. V. Efemov, Yu. V. Nacharov, and G. S. Yakobson, “Disturbances of electrolyte balance in the genesis of myocardial lesions in long-term compression syndrome in rats with inherited arterial hypertension,” Byul. Sib. Otdel Ros. Akad. Med. Nauk., No. 3, 129–132 (1996).Google Scholar
  2. 2.
    N. K. Arokina and A. M. Zharikov, “Effects of EDTA on the spike activity of cold thermoreceptors and mechanoreceptors in the skin in conditions of profound cooling,” Fiziol. Zh. im. I. M. Sechenova, 81, No. 12, 24–30 (1995).Google Scholar
  3. 3.
    A. V. Efremov and A. R. Antonov, The Lymphatic System, Stress, Metabolism [in Russian], Novosibirsk Medical Institute, Novosibirsk (1999).Google Scholar
  4. 4.
    K. P. Ivanov, “Changes in physiological functions, mechanisms of restoration, and the temperature limits of life in hypothermia,” Usp. Fiziol. Nauk., 27, No. 3, 84–105 (1996).PubMedGoogle Scholar
  5. 5.
    T. V. Kozyreva, “Effects of calcium ions on temperature sensitivity in humans,” Fiziol. Cheloveka, 9, No. 4, 671–672 (1983).Google Scholar
  6. 6.
    P. G. Kostyuk, Calcium and Cellular Excitability [in Russian], Nauka, Moscow (1986).Google Scholar
  7. 7.
    S. V. Lomakina, E. Ya. Tkachenko, and T. V. Kozyreva, “Formation of thermoregulatory reactions on cooling in rats with inherited arterial hypertension,” Byull. Éksperim. Biol. Med., 130, No. 11, 504–507 (2002).Google Scholar
  8. 8.
    M. J. Berridge, M. D. Bootman, and P. Lipp, “Calcium-a life and death signal,” Nature, 395, 645–648 (1998).PubMedCrossRefGoogle Scholar
  9. 9.
    S. N. Davies, G. E. Goldsmith, R. F. Hellon, and D. Mitchell, “Facial sensitivity to rates of temperature change. Neurophysiological and psychophysiological evidence from cats and humans,” J. Physiol. (London), 344, 161–175 (1983).Google Scholar
  10. 10.
    M. Endo and T. Kitazawa, “Calcium ions and contraction of smooth muscle by alpha-adrenergic stimulation,” in: Calcium Entry Blockers and Tissue Protection, T. Godfrained et al. (eds.), Raven Press, New York (1985), pp. 81–85.Google Scholar
  11. 11.
    J.P. Horn and D. A. McAfee, “Alpha-adrenergic inhibition of calcium-dependent potentials in rat sympathetic neurones,” J. Physiol. (London), 30, 191–204 (1980).Google Scholar
  12. 12.
    T. V. Kozyreva, “Two periods in the response of the skin cold receptors to intravenous infusion noradrenaline,” Ann. N.Y. Acad. Sci., 813: Thermoregulation, C. Blatteis (ed.), 176–183 (1997).Google Scholar
  13. 13.
    T. V. Kozyreva, E. Ya. Tkachenko, and V. P. Kozaruk, “Thermoregulatory responses to cooling before and after the noradrenaline iontophoresis to skin,” J. Therm. Biol., 24, 175–183 (1999).CrossRefGoogle Scholar
  14. 14.
    T. V. Kozyreva, E. Ya. Tkachenko, V. P. Kozaruk, T. V. Latysheva, and M. A. Gilinsky, “Effects of slow and rapid cooling on catecholamine concentration in arterial plasma and the skin,” Amer. J. Physiol., 276, R1668–R1672 (1999).Google Scholar
  15. 15.
    S. Z. Langer, “Presynaptic regulation of the release of catecholamine,” Pharmacol. Rev., 32, 337–362 (1980).PubMedGoogle Scholar
  16. 16.
    A. L. Markel, Genetic Hypertension, J. Sassard (ed.), INSERT Colloquium, John Libbey Eurotext, London (1992), Vol. 218, pp. 405–407.Google Scholar
  17. 17.
    A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and S. Rahamimoff, “Ion channels in presynaptic terminals and control of transmitter release,” Physiol. Rev., 79, 1019–1088 (1999).PubMedGoogle Scholar
  18. 18.
    L. de Meis, “Control of heat production by the Ca2+-ATPase of rabbit and trout sarcoplasmic reticulum,” Amer. J. Physiol., 274, No. 6, 1738–1744 (1998).Google Scholar
  19. 19.
    M. Okazawa, K. Takao, A. Hori, T. Shiraki, K. Matsumura, and S. Kobayashi, “Ionic basis of cold receptors acting as thermostats,” J. Neurosci., 22, No. 10, 3994–4001 (2002).PubMedGoogle Scholar
  20. 20.
    Fr.-K. Pierau, R. D. Wurster, and J. Ulrich, “The effect of low and high Ca-concentration on ouabain treated lingual cold receptors in the cat,” J. Therm. Biol., 8, 19–22 (1983).CrossRefGoogle Scholar
  21. 21.
    K. Schaffer and H. A. Brain, “Modulation of cutaneous cold receptor function by electrolytes, hormones and thermal adaptation,” Physiol. Res., 41, No. 1, 71–75 (1992).PubMedGoogle Scholar
  22. 22.
    Z. Szreder, “Comparison between thermoregulatory effects mediated by alpha 1-and 2-adrenoreceptors in normothermic and febrile rabbits,” Gen. Pharmacol., 24, No. 4, 929–941 (1993).PubMedGoogle Scholar
  23. 23.
    J. M. Ye, S. J. Edwards, R. W. Rose, J. T. Steen, M. G. Clark, and E. Q. Colquhoun, “Alpha-adrenergic stimulation of thermogenesis in a rat kangaroo,” AJP-Regulatory, Integrative, and Comparative Physiology, 271, No. 3, R586–R592 (1996).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • T. V. Kozyreva
    • 1
  • S. V. Lomakina
    • 1
  • E. Ya. Tkachenko
    • 1
  • A. L. Markel’
    • 1
  1. 1.Thermophysiology Laboratory, State Research Institute of Physiology, Siberian BranchRussian Academy of Medical SciencesNovosibirskRussia

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