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Neuroscience and Behavioral Physiology

, Volume 37, Issue 5, pp 509–515 | Cite as

Effects of activation and blockade of NMDA receptors on the extinction of a conditioned passive avoidance response in mice with different levels of anxiety

  • R. A. Tomilenko
  • N. I. Dubrovina
Article

Abstract

The effects of an agonist (D-cycloserine) and an antagonist (dizocilpine) of N-methyl-D-aspartate (NMDA) receptors on the learning and extinction of a conditioned passive avoidance response were studied in mice with low, intermediate, and high levels of anxiety. In intermediate-anxiety mice, D-cycloserine (30 mg/kg) had no effect on learning but accelerated extinction, while dizocilpine (0.15 mg/kg) degraded acquisition of the reflex but delayed extinction. In high-anxiety mice, with good learning and no extinction, D-cycloserine had no effect, while dizocilpine decreased learning and facilitated retention of performance of the memory trace at the ongoing level in conditions promoting extinction. In low-anxiety mice, D-cycloserine degraded learning and accelerated extinction, while dizocilpine completely blocked learning and the retention of the passive avoidance response.

Key words

memory passive avoidance extinction anxiety NMDA receptors 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • R. A. Tomilenko
    • 1
  • N. I. Dubrovina
    • 1
  1. 1.State Research Institute of Physiology, Siberian DivisionRussian Academy of Medical SciencesNovosibirskRussia

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