Neuroscience and Behavioral Physiology

, Volume 36, Issue 5, pp 527–530 | Cite as

Apoptosis of hypothalamic neurosecretory cells in stress mice at different stages of ontogenesis

  • Yu. V. Abatnina
  • E. D. Bazhanova
  • D. L. Teplyi


The aim of the present work was to identify the role of cycloferon in the apoptosis of cells in the neurosecretory centers of the hypothalamus in young and old mice in conditions of immobilization stress. Apoptotic cells were identified by staining with ethidium bromide. The optical density of the detection product of the antiapoptotic protein Bcl-2 was also studied in cells of the supraoptic and paraventricular (PVN) nuclei. Cycloferon was found to decrease the level of apoptosis in the neurosecretory centers of the hypothalamus via a Bcl-2-independent pathway. Administration of cycloferon before stress had no effect on the number of apoptotic cells, except in the PVN of old mice, where apoptosis was inhibited.

Key words

hypothalamus apoptosis cycloferon aging stress 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Yu. V. Abatnina
    • 1
  • E. D. Bazhanova
    • 2
  • D. L. Teplyi
    • 1
  1. 1.Department of Human and Animal Anatomy and PhysiologyAstrakhan State UniversityRussia
  2. 2.Laboratory for Comparative Somnology and Neuroendocrinology (Director: Doctor of Medical Sciences G. A. Oganesyan) I. M. Sechenov Institute of Evolutionary PhysiologyRussian Academy of SciencesSt. Petersburg

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