Acquisition and extinction of a conditioned passive avoidance reflex in mice with genetic knockout of monoamine oxidase A
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We report here the results obtained from comparative analysis of learning and the dynamics of extinction of a conditioned passive avoidance response in mice with genetic knockout of monoamine oxidase A (MAO A) and the progenitor line C3H. Mice of both lines acquired the conditioned passive avoidance reaction efficiently. Mice with genetic knockout of MAO A were characterized by prolonged retention of reproduction of the memory trace, as compared with rapid extinction in C3H mice. Smaller numbers of transfers, and vertical rearings on days 7–13 and the numbers of glances into and rom the dark sector on days 11–13 of extinction in MAO A-knockout mice appear to reflect their more marked fear reactions when confronted with the “dangerous” sector, along with increased anxiety, these facilitating longer-lasting retention of the memory trace.
Key wordsgenetic knockout reproduction passive avoidance memory extinction MAO A
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- 1.N. I. Dubrovina and L. V. Loskutova, Dopaminergic Mechanisms of Memory and Attention [in Russian], Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk (2003).Google Scholar
- 2.I. P. Lapin, “Decreases in the frequency of glancing from a dark sector — the single consistent measure of the effects of anxiogens on behavior in mice in the ‘light-dark’ chamber,” Zh. Vyssh. Nerv. Deyat., 49, No. 3, 521–536 (1999).Google Scholar
- 4.N. K. Popova, Yu. A. Skrinskaya, T. G. Amstislavskaya, S. B. Vishnivetskaya, I. Seif, and E. D. Maier, “Characteristics of the behavior of mice with genetic knockout of monoamine oxidase A,” Zh. Vyssh. Nerv. Deyat., 50, No. 6, 991–999 (2000).Google Scholar
- 5.E. N. Sokolov and N. I. Nezlina, “Long-term memory, neurogenesis, and the novelty signal,” Zh. Vyssh. Nerv. Deyat., 53, No. 4, 451–461 (2003).Google Scholar
- 11.M. Frnak and J. J. Braszko, “Moclobemide enhances aversively motivated learning and memory in rats,” Pol. J. Pharmacol., 51, 497–503 (1999).Google Scholar
- 22.R. L. Riberio, R. Andreatini, C. Wolfman, H. Viola, J. H. Medina, and C. Da Cunha, “The ‘anxiety state’ and its relation with rat models of memory and habituation,” Neurobiol. Learn. Mem., 72, 78–94 (1999).Google Scholar
- 30.M. B. Vianna, F. G. Graeff, and P. A. Laschmann, “Kainate microinjection into the dorsal raphe nucleus induces 5-HT release in the amygdala and periaqueductal gray,” Pharmacol. Biochem. Behav., 58, 167–172 (1997).Google Scholar