Abstract
Measurements of mean spike frequencies and plotting of autocorrelation histograms were performed to study the nature of the spike activity of individual neurons in the lateral hypothalamus and central nucleus of the amygdala from bilateral leads in rabbits in calm waking, after 24-h food deprivation, and after satiation. The nature of neuron spike activity changed in different ways in the hypothalamus and amygdala on transfer from hunger to satiation: 1) the mean spike frequency changed in more hypothalamic (85%) than amygdalar (56%) cells; 2) as compared with calm waking and satiation, hunger was associated with a decrease in the number of neurons with periodic discharges in the delta frequency range in the hypothalamus, while the amygdala showed an increase in periodic discharges in the beta-2 frequency range; 3) in hunger, the hypothalamus showed a decrease in the number of neurons with burst and periodic discharges, while the amygdala showed increases in the number with equiprobabilistic discharge activity. Assessed in terms of autocorrelation histogram shape, greater changes in the nature of neuron spike activity associated with changes in state occurred on the left side than on the right in both the hypothalamus and amygdala. The maximal differences in neuron spike activity on the right and left sides in the hypothalamus were seen in hunger; the greatest differences in the amygdala were seen in satiation.
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REFERENCES
O. S. Adrianov, “Cerebral interrelationships between cognitive and emotional activity: pathways and mechanisms,” Zh. Vyssh. Nerv. Deyat., 45, No.3, 441–452 (1995).
P. G. Bogach and B. L. Ganzha, “High-frequency synchronized activity in the amygdaloid complex as an EEG measure of various psychophysiological states,” in: Questions of Hypothalamic Physiology [in Russian], University of Kiev, Kiev (1973), No. 7, pp. 3–18.
Ya. Buresh, M. Petran', and I. Zakhar, Electrophysiological Research Methods [in Russian], Izdatel'stvo Inostrannoi Literatury (Foreign Literature Press), Moscow (1962).
V. A. Geodakyan, “Asynchronous asymmetry,” Zh. Vyssh. Nerv. Deyat., 43, No.3, 543–561 (1993).
R. Yu. Il'yuchenok, M. A. Gilinskii, L. V. Loskutova, N. I. Dubrovina, and N. V. Vol'f, The Amygdaloid Complex (Connections, Behavior, Memory) [in Russian], Nauka, Novosibirsk (1981).
A. K. Malikova and E. V. Petrova, “Thermal activity of the rabbit brain in the motivational states of hunger and thirst,” Zh. Vyssh. Nerv. Deyat., 48, No.4, 623–629 (1998).
N. G. Mikhailova and E. I. Kuliev, “Neuronal activity in hypothalamic self-stimulation zones in motivational and emotional states induced by electrical and natural stimuli,” Zh. Vyssh. Nerv. Deyat., 36, No.5, 939–946 (1986).
I. V. Pavlova, “Interaction of rabbit neocortex neurons in natural food-related motivation,” Zh. Vyssh. Nerv. Deyat., 46, No.1, 108–116 (1996).
I. V. Pavlova, “Linkage of spike activity in the right and left lateral hypothalamus in food motivation,” Zh. Vyssh. Nerv. Deyat., 51, No.4, 461–466 (2001).
I. V. Pavlova, I. V. Volkov, and V. N. Mats, “The effects of stimulation of the lateral hypothalamus on the linked spike activity of neurons in the rabbit neocortex,” Zh. Vyssh. Nerv. Deyat., 46, No.6, 1068–1074 (1996).
I. V. Pavlova and V. N. Mats, “Functional asymmetry in the lateral hypothalamus of the rabbit in food motivation,” Zh. Vyssh. Nerv. Deyat., 46, No.4, 740–744 (1996).
R. A. Pavlygina and Yu. V. Lyubimova, “Spectral characteristics of brain electrical activity in rabbits in the state of hunger,” Zh. Vyssh. Nerv. Deyat., 44, No.1, 57–64 (1994).
P. V. Simonov, The Motivated Brain [in Russian], Nauka, Moscow (1987).
N. F. Suvorov, L. K. Danilova, S. I. Shefer, and V. T. Shuvaev, “Involvement of the amygdala in evaluating the biological significance of conditioned stimuli,” Fiziol. Zh. SSSR, 69, No.3, 304–312 (1983).
K. V. Sudakov, B. V. Zhuravlev, A. A. Kromin, N. N. Shamaev, and L. V. Timofeeva, “Reflection of the dominant motivation in the activity of brain neurons and peripheral organs,” Usp. Fiziol. Nauk., 19, No.3, 24–44 (1988).
I. P. Tsvetkova, The Rabbit Hypothalamus. A Stereotaxic and Cytoarchitectonic Atlas [in Russian], Nauka, Leningrad (1978).
S. A. Chepurnov and N. E. Chepurnova, The Amygdaloid Complex of the Brain [in Russian], Moscow State University Press, Moscow (1981).
V. T. Shuvaev, “The amygdalo-caudate system and behavior,” Usp. Fiziol. Nauk., 24, No.2, 84–108 (1993).
R. E. Adamec, “Evidence that long-lasting potentiation in limbic circuits mediating defensive behaviour in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of benzodiazepine receptors,” J. Psychopharmacol., 14, No.4, 307–322 (2000).
R. Adamec and B. Yong, “Neuroplasticity in specific limbic system circuits may mediate specific kindling induced changes in animal affect-implications for understanding anxiety associated with epilepsy,” Neurosci. Biobehav. Rev., 24, No.7, 705–723 (2000).
R. Adolphs, D. Tranel, and H. Damasio, “Emotion recognition from faces and prosody following temporal lobectomy,” Neuropsychology, 15, No.3, 396–404 (2001).
A. K. Anderson, D. D. Spencer, R. K. Fulbright, and E. A. Phelps, “Contribution of the anteromedial temporal lobes to the evaluation of facial emotion,” Neuropsychology, 14, No.4, 526–536 (2000).
I. Belcheva, S. Belcheva, V. V. Petkov, and V. D. Petkov, “Asymmetry in behavioral responses to cholecystokinin microinjected into rat nucleus accumbens and amygdala,” Neuropharmacology, 33, No.8, 995–1002 (1994).
K. Coleman-Mesches, J. A. Salinas, and J. L. McGaugh, “Unilateral amygdala inactivation after training attenuates memory for reduced reward,” Behav. Brain Res., 77, No.1–2, 175–180 (1996).
E. Fonberg, “Amygdala functions within the alimentary system,” Acta Neurobiol. Exp., 34, 435–466 (1974).
M. Fukuda and T. Ono, “Amygdala-hypothalamic control of feeding behavior in monkey: single cell responses before and after reversible blockade of temporal cortex or amygdala projections,” Behav. Brain Res., 55, No.2, 233–241 (1993).
E. S. Funayama, C. Grillon, M. Davis, and E. A. Phelps, “A double dissociation in the affective modulation of startle in humans: effects of unilateral temporal lobectomy,” J. Cogn. Neurosci., 13, No.6, 721–729 (2001).
T. Furmark, H. Fischer, G. Wik, M. Larsson, and M. Fredrikson, “The amygdala and individual differences in human fear conditioning,” Neuroreport, 8, No.18, 3957–3960 (1997).
P. Gloor, “Inputs and outputs of the amygdala-what the amygdala is trying to tell the rest of the brain,” in: Limbic Mechanisms: The Continuing Evolution of the Limbic System Concept, K. E. Livingston and O. Hornykeiarez (eds.), Plenum Press, New York (1978), pp. 189–209.
Z. Karadi, Y. Oomura, H. Nishino, T. R. Scott, L. Lenard, and S. Aou, “Responses of lateral hypothalamic glucose-sensitive and glucose-insensitive neurons to chemical stimuli in behaving rhesus monkey,” J. Neurophysiol., 67, No.2, 389–400 (1992).
L. Lenard, Z. Karadi, B. Faludi, and I. Hernadi, “Role of forebrain glucose-monitoring neurons in the central control of feeding: I. Behavioral properties and neurotransmitter sensitivities,” Neurobiology, 3, No.3–4, 223–239 (1995).
J. S. Morris, A. Ohman, and R. J. Dolan, “Conscious and unconscious emotional learning in the human amygdala,” Nature, 393, No.6684, 467–470 (1998).
T. Ono, H, Nishijo, and H. Hishino, “Functional role of the limbic system and basal ganglia in motivated behaviors,” J. Neurol., 247,Suppl. 5, 23–32 (2000).
T. Ono, R. Tamura, H. Nishijo, K. Nakamura, and E. Tabuchi, “Contribution of amygdalar and lateral hypothalamic neurons to visual information processing of food and nonfood in monkey,” Physiol. Behav., 45, No.2, 411–421 (1989).
E. T. Rools, “Memory systems in the brain,” Ann. Rev. Psychological., 51, 599–630 (2000).
F. Scneider, W. Grodd, U. Weiss, U. Klose, K. R. Mayer, T. Nagele, and R. C. Gur, “Functional MRI reveals amygdala activation during emotion,” Psychiatry Res., 76, No.2–3, 75–82 (1997).
M. H. Tabert, J. C. Borod, C. Y. Tang, G. Lange, T. C. Wei, R. Johnson, A. O. Nusbaum, and M. S. Buchsbaum, “Differential amygdala activation during emotional decision and recognition memory tasks using unpleasant words: an fMRI study,” Neuropsychologia, 39, No.6, 556–573 (2001).
T. Zalla, E. Koechlin, P. Pietrini, G. Basso. P. Aquino, A. Sirigu, and J. Grafman, “Differential amygdala responses to winning and losing: a functional magnetic resonance imaging study in humans,” Eur. J. Neurosci., 12, No.5, 1764–1770 (2000).
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 54, No. 6, pp. 776–784, November–December, 2004.
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Pavlova, I.V. Spike Activity of Neurons in the Amygdala and Hypothalamus in Bilateral Leads in Food Motivation. Neurosci Behav Physiol 36, 193–201 (2006). https://doi.org/10.1007/s11055-005-0178-y
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DOI: https://doi.org/10.1007/s11055-005-0178-y