Abstract
The experiments reported here demonstrated that corasol increased the extent of analgesia induced by stress and decreased the duration of immobility in mice in a forced swimming test in cold water. Administration of diazepam led to the opposite changes and counteracted the actions of the anxiogen. The effects of the anxiolytic were more apparent in NMRI than mongrel mice, while in mongrel mice the effects of the anxiogen were more marked. Changes in measures following administration of agents were reciprocal in nature. These results lead to the conclusion that that these changes are determined by the level of anxiety, and that the strain differences between mongrel and NMRI mice are also linked with this factor.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
O. G. Kenunen and V. L. Kozlovskii, “Stress-induced analgesia in animals — a model of depersonalization in humans?” Obozr. Psikhiatr. Med. Psikhol. im. V. P. Bekhtereva, No. 1, 51–53 (2000).
O. G. Kenunen, I. V. Prakh'e, and V. L. Kozlovskii, “The extent of stress-induced analgesia is linked to the activity of animals in a forced swimming test,” Zh. Vyssh. Nerv. Deyat., 51, No.5, 626–630 (2001).
A. Armario, M. Gil, J. Marti, O. Pol, and J. Balasdh, “Influence of various acute stressors on the activity of adult male rats in a holeboard and in the forced swim test,” Pharmacol. Biochem. Behav., 39, No.2, 373–377 (1991).
R. L. Bell, R. D. Soigner, R. D. Olson, and A. L. Vaccarino, “Reduction of stress-induced analgesia following ethanol exposure in mice,” Life Sci., 63, No.9, 731–736 (1998).
J. W. Blaszczyk, K. Tajchert, I. Lapo, and B. Sadowski, “Acoustic startle and open field behavior in mice bred for magnitude of swim analgesia,” Physiol. Behav., 70, No.5, 659–671 (2000).
J. E. Blustain, L. Ciccolone, and P. J. Bersh, “Evidence that adaptation to cold water swim-induced analgesia is a learned response,” Physiol. Behav., 63, No.1, 147–150 (1997).
R. J. Bodnar, D. D. Kelly, A. Spiaggia, and H. Glusman, “Stress-induced analgesia: adaptation following chronic cold-water swim,” Bull. Psychol. Soc., 11, 337–340 (1978).
R. J. Bodnar, P. E. Mann, and E. A. Stone, “Potentiation of coldwater swim analgesia by acute, but not chronic desimipramine administration,” Pharmacol. Biochem. Behav., 23, No.5, 749–752 (1985).
T. J. Coderre and G. B. Rollman, “Stress analgesia: effects of PCPA, yohimbine, and naloxone,” Pharmacol. Biochem. Behav., 21, No.5, 681–686 (1984).
A. C. N. De Souza, R. L. De Souza, I. R. Pela, and F. G. Graeff, “High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors,” Pharmacol. Biochem. Behav., 56, No.3, 481–486 (1997).
M.-N. Girardot and F. A. Holloway, “Intermittent cold water stress-analgesia in rats: cross-tolerance to morphine,” Pharmacol. Biochem. Behav., 20, No.4, 631–633 (1984).
G. Griebel, C. Belzung, G. Perrault, and D. J. Sanger, “Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice,” Psychopharmacol., 148, No.2, 164–170 (2000).
W. Haefely, “Benzodiazepine interactions with GABA receptors,” Neurosci. Lett., 47, No.3, 201–206 (1984).
T. Hata and H. Nishikawa, “Behavioral characteristics of SART-stressed mice in the forced swim test and drug action,” Pharmacol. Biochem. Behav., 51, No.4, 849–853 (1995).
K. L. Kepler and R. J. Bodnar, “Yohimbine potentiates cold-water swim analgesia: reevaluation of a noradrenergic role,” Pharmacol. Biochem. Behav., 29, No.1, 83–88 (1988).
S. M. Korte, E. R. De Kloet, B. Buwalda, S. D. Bouman, and B. Bohus, “Antisense to the glucocorticoids receptor in hippocampal dentate gyrus reduces immobility in forced swim test,” Eur. J. Pharmacol., 301, No.1–3, 19–25 (1996).
D. S. Leitner and D. D. Kelly, “Potentiation of cold swim stress analgesia in rats by diazepam,” Pharmacol. Biochem. Behav., 21, No.5, 813–816 (1984).
J. Marti and A. Armario, “Effects of diazepam and desipramine in the forced swimming test: influence of previous experience with the situation,” Eur. J. Pharmacol., 236, No.2, 295–299 (1993).
H. Nishimura, Y. Ida, A. Tsuda, and M. Tanaka, “Opposite effects of diazepam and b-CCE on immobility and straw-climbing behavior of rats in a modified forced-swim test,” Pharmacol. Biochem. Behav., 33, No.1, 227–229 (1989).
R. D. Porsholt, A. Lenegre, and R. A. McArthur, “Pharmacological models of depression,” in: Animal Models in Pharmacology. Advances in Pharmacological Sciences, Birkhanser Verlag, Basel (1991), pp. 137–159.
L. C. Rovati, P. Sacerdote, P. Fumagalli, M. Bianchi, P. Mantegazza, and A. E. Panerai, “Benzodiazepines and their antagonists interfere with opioid-dependent stress-induced analgesia,” Pharmacol. Biochem. Behav., 36, No.1, 123–126 (1990).
Author information
Authors and Affiliations
Additional information
__________
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 90, No. 12, pp. 1555–1562, December, 2004.
Rights and permissions
About this article
Cite this article
Kenunen, O.G., Prakh'e, I.V. & Kozlovskii, V.L. Changes in Anxiety Levels Are Followed by Changes in Behavioral Strategy in Mice Subjected to Stress and in the Extent of Stress-Induced Analgesia. Neurosci Behav Physiol 36, 151–156 (2006). https://doi.org/10.1007/s11055-005-0173-3
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/s11055-005-0173-3