Abstract
Forty patients with ischemic heart disease and undergoing aortocoronary shunting surgery with cardiopulmonary bypass were studied. All patients were subjected to neuropsychological assessment and immunochemical analysis of the production of chemokines (IL-8, IP-10, MCP-1, MCP-3, MIP-1β, SDF-1α) and cytokines (TNF-α and IL-10). The aims of the study were to assess the presence and severity of cognitive deficit developing after surgery with cardiopulmonary bypass and to assess the effects of intraoperative Trasylol on its severity. Cognitive deficit on day 9 after coronary shunting with cardiopulmonary bypass was seen as impairments of attention, hearing-speech memory, visual memory, and dynamic praxis. Trasylol had a marked neuroprotective effect and suppressed the systemic inflammatory response. Patients given intraoperative Trasylol had no clinically significant cognitive deficit in the early post-operative period.
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REFERENCES
L. A. Kokeriya, I. I. Berishvili, and I. Yu. Sigaev, Minimally Invasive Revascularization of the Myocardium [in Russian], A. N. Bakulev Scientific Center for Cardiovascular Surgery Press, Russian Academy of Medical Sciences, Moscow (2001).
E. Bianchi, J. R. Bender, F. Blasi, and R. Pardi, “Through and beyond the wall: late steps in leukocyte transendothelial migration,” Immunol. Today, 18, 586–591 (1997).
G. B. Bulkley, “Free radical-mediated reperfusion injury: a selective review,” Brit. J. Cancer, Suppl., 8, 66–73 (1987).
J. Butler, G. M. Rocker, and S. Westaby, “Inflammatory response to cardiopulmonary bypass,” Ann. Thorac. Surg., 55, 552–559 (1993).
J. J. Campbell, J. Jedrick, A. Zlotnik, et al., “Chemokines and the arrest of lymphocytes rolling under flow conditions,” Science, 279, 381–384 (1998).
J. C. Cutrn, M. G. Perrelli, B. Cavalieri, et al., “Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning,” Free Radic. Biol. Med., 33, 1200–1208 (2002).
M. E. Ergin et al., “Temporary neurological dysfunction after deep hyperthermic circulatory arrest: a clinical marker of long-term functional deficit,” Ann. Thorac. Surg., 67, 1887–1890 (1999).
J. H. Garcia, K. F. Liu, Y. Yoshida, et al., “Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat),” Amer. J. Pathol., 144, 188–199 (1994).
A. Grasso, G. Roda, R. A. Hogue-Angeletti, et al., “Preparation and properties of the brain-specific protein 14-3-2,” Brain Res., 124, No.3, 479–507 (1977).
C. S. Isbir, R. Dogan, M. Demircin, et al., “Aprotinin reduces the IL-8 after coronary artery bypass grafting,” Cardiovasc. Surg., 9, 403–406 (2001).
B. Krishnadasan, E. N. Morgan, E. D. Boyle, and E. D. Verrier, “Mechanisms of myocardial injury after cardiac surgery,” J. Cardiothorac. Vasc. Anesth., 14, 6–10 (2000).
H. L. Li, N. Kostulas, Y. M. Huang, et al., “IL-17 and IFN-gamma mRNA expression is increased in the brain and systemically after permanent middle cerebral artery occlusion in the rat,” J. Neuroimmunol., 116, 5–14 (2001).
K. Nandate et al., “Cerebrovascular cytokine responses during coronary artery bypass surgery: specific production of interleukin-8 and its attenuation by hypothermic cardiopulmonary bypass,” Anesth. Analg., 89, 823–828 (1999).
S. Newman, “The incidence and nature of neuropsychological morbidity following cardiac surgery,” Perfusion, 4, 93–100 (1989).
L. S. Rasmussen et al., “Do blood levels of neuron-specific enolase and S-100 protein reflect cognitive dysfunction after coronary artery bypass?” Acta Anaesthesiol. Scand., 43, 495–500 (1999).
K. M. Taylor, “Cardiac surgery and the brain: An introduction,” in: Cardiac Surgery and the Brain, London (1993), pp. 1–14.
A. Turkoz, A. Cigli, K. But, et al., “The effects of aprotinin and steroids on generation of cytokines during coronary artery surgery,” J. Cardiothorac. Vasc. Anesth., 15, 603–610 (2001)
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 105, No. 1, pp. 30–35, January, 2005.
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Buziashvili, Y.I., Ambat'ello, S.G., Aleksakhina, Y.A. et al. Influence of Cardiopulmonary Bypass on the State of Cognitive Functions in Patients with Ischemic Heart Disease. Neurosci Behav Physiol 36, 107–113 (2006). https://doi.org/10.1007/s11055-005-0168-0
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DOI: https://doi.org/10.1007/s11055-005-0168-0