Neuroscience and Behavioral Physiology

, Volume 36, Issue 1, pp 29–34 | Cite as

Hematological Parameters in Wistar Rats in Conditions of Stress and Treatment with Heparin

  • M. V. Kondashevskaya
  • V. A. Mkhitarov


The effects on hematological measures of emotional tension arising during the formation of food-procuring behavior in a multiple-choice maze and in conditions of pain (injection of 0.85% physiological saline i.m., 0.3 ml, daily for five days) were studied in Wistar rats. Physiological saline and training of intact animals led to increases in RBC volume and mean corpuscular hemoglobin content, accompanied by significant increases in plasma corticosterone levels. At the same time, neither heparin (standard unfractionated heparin, Serva, doses of 64 and 640 IU/kg, daily for five days) nor training of heparinized rats produced any changes in these measures. The high levels of organization of the acquired behavior and the working capacity seen in heparinized rats were evidence for improvements in both the associative properties of conditioned reflex activity and the mechanisms supporting stable reproduction of the acquired habit. After administration of heparin, rats lost all types of manifestation reflecting psychoemotional tension as generally seen in animals in the active (administration of physiological saline) and passive (intact rats) controls.

Key Words

heparin learning pain hematological measures Wistar rats 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • M. V. Kondashevskaya
    • 1
  • V. A. Mkhitarov
    • 1
  1. 1.State Science Research Institute of Human MorphologyRussian Academy of Medical Sciences, Functional Morphology of Stress GroupMoscowRussia

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