Abstract
Prolonged exposure of females to negative psychoemotional conditions by permanent keeping with aggressive males on the other side of a perforated partition in a cage with daily witnessing of intermale confrontations had negative influences on the behavior of females, assessed using a variety of ethological tests. The elevated maze test and the open field test provided evidence for the development of marked anxiety in the females, with inhibition of motor and investigative activity. Decreases in the responses of females close to the partition to familiar and unfamiliar males one month after the onset of exposure to negative psychoemotional conditions and before the end of the experiment provided evidence for a decrease in communicativeness. After two months of exposure to negative psychoemotional conditions, intermale confrontations also ceased to interest females, as shown by the partition test. The hotplate test revealed worsening of pain sensitivity in experimental females. More than half of the individuals demonstrated impairment to the cyclicity of sexual cycles with increases in the duration of diestrus. After being kept in negative psychoemotional conditions, females ceased to differentiate littermates by social status and gender, as shown by social/sexual recognition tests. All these data provide grounds for suggesting the development of an anxious-depressive state in females after being kept in negative psychoemotional conditions for prolonged periods.
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REFERENCES
D. F. Avgustinovich, “Anxiety in females induced by prolonged exposure to negative psychoemotional conditions,” Ros. Fiziol. Zh. im. I. M. Sechenova, 89, No.7, 858–867 (2003).
D. F. Avgustinovich, N. A. Lyudvina, V. V. Dolgov, and O. V. Alekseenko, “Effects of prolonged restriction stress on the behavior of female mice of the inbred strains C57BL/6J and CBA/Lac. Dispersion and cluster analysis,” Ros. Fiziol. Zh. im. I. M. Sechenova, 87, No.9, 1268–1282 (2001).
D. F. Avgustinovich and I. L. Kovalenko, “Prolonged individual keeping of C57BL/6J mice leads to anxiety, ” Ros. Fiziol. Zh. im. I. M. Sechenova, 90, No.3, 1268–1282 (2004).
E. G. Filatova and A. M. Vein, “Motivational and endocrine disturbances in depression,” Psikhiatr. Psikhofarmakoterapiya, 1 (2000).
S. J. Alonso, M. A. Castellano, D. Afonso, and M. Rodrigues, “Sex differences in behavioral despair: relationships between behavioral despair and open field activity,” Physiol. Behav., 49, 69–72 (1991).
D. F. Avgustinovich, O. V. Gorbach, and N. N. Kudryavtseva, “Comparative analysis of anxiety-like behavior in the partition and plus-maze tests after agonistic interactions in mice,” Physiol. Behav., 61, No.1, 37–43 (1997).
D. F. Avgustinovich, T. V. Lipina, N. P. Bondar, O. V. Alekseyenko, and N. N. Kudryavtseva, “Features of the genetically defined anxiety in mice,” Behav. Genet., 30, No.2, 101–109 (2000).
A. W. Bannon, J. Seda, M. Carmouche, J. M. Francis, M. H. Norman, B. Karbon, and M. L. McCaleb, “ Behavioral characterization of neuropeptide Y knockout mice,” Brain Res., 868, 79–87 (2000).
H. M. T. Barros and M. Ferigolo, “Ethopharmacology of imipramine in the forced-swimming test: gender differences,” Neurosci. Biobehav. Rev., 23, 279–286 (1998).
A. Bartolomucci, T. Pederzani, P. Sacerdote, A. E. Panerai, S. Parmigiani, and P. Palanza, “Behavioral and physiological characterization of male mice under chronic psychosocial stress,” Psychoneuroendocrinol., 29, 899–910 (2004).
R. J. Blanchard, C. R. McKittrick, and D. C. Blanchard, “Animal models of social stress: effects on behavior and brain neurochemical system,” Physiol. Behav., 73, 261–271 (2001).
K. Bjorqvist, “Social defeats as a stressor in humans,” Physiol. Behav., 73, 435–442 (2001).
M. Bourin, E. Mocaer, and R. Porsholt, “Antidepressant-like activity of S 10098 (agomelantine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors,” J. Psychiatry Neurosci., 29, No.2, 126–133 (2004).
L. A. Brotto, A. M. Barr, and B. B. Gorzalka, “Sex differences in forced-swim and open-field test behaviors after chronic administration of melatonin,” Eur. J. Pharmacol., 402, 87–93 (2000).
E. Choleris, M. Kavaliers, and D. W. Pfaff, “Functional genomics of social recognition,” J. Neuroendocrinol., 16, 383–389 (2004).
A. Dalvi and I. Lucki, “Murine models of depression,” Psychopharmacol., 147, 14–16 (1999).
F. Earls, “Sex differences in psychiatric disorders: origins and developmental influences,” Psychiatr. Dev., 5, 1–23 (1987).
M. Kavaliers, D. D. Colwell, W. J. Braun, and E. Choleris, “Brief exposure to the odour of a parasitized male alters the subsequent mate odour responses of female mice,” Anim. Behav., 65, 59–86 (2003).
A. J. Keeney and S. Hogg, “Behavioural consequences of repeated social defeat in the mouse: evolutionary evaluation of potential animal model of depression,” Behav. Pharmacol., 10, 753–764 (1999).
G. A. Kennett, F. Chaouloff, M. Marcou, and G. Curzon, “Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin,” Brain Res., 382, 416–421 (1986).
J. W. Kim and B. Kirkpatrick, “Social isolation in animal models of relevance to neuropsychiatric disorders,” Biol. Psychiatr., 40, 918–922 (1996).
S. M. Korte, “Corticosteroids in relation to fear, anxiety and psychopathology,” Neurosci. Biobehav. Rev., 25, 117–142 (2001).
N. N. Kudryavtseva and D. F. Avgustinovich, “Behavioral and physiological markers of experimental depression induced by social conflicts (DISC),” Aggress. Behav., 24, No.4, 271–286 (1998).
N. N. Kudryavtseva, I. V. Bakshtanovskaya, and L. A. Koryakin, “Social model of depression in mice of C57BL/6J strain,” Pharmacol. Biochem. Behav., 38, No.2, 315–320 (1991).
R. Lister, “The use of a plus-maze to measure anxiety in the mouse,” Psychopharmacol., 92, 180–195 (1987).
D. H. Overstreet, O. Pucilowski, M. C. Retton, P. Delagrange, and B. Guardiola-Lemaitre, “Effects of melatonin receptor ligands on swim test immobility,” 9, 249–253 (1998).
P. Palanza, L. Gioisa, and S. Parmigiani, “Social stress in mice: gender differences and effects of estrous cycle and social dominance,” Physiol Behav., 73, 411–420 (2001).
R. D. Porsholt, G. Anton, N. Blaver, and M. Jalfre, “Behavioural despair in rats: a new model sensitive to antidepressant treatment,” Eur. J. Pharmacol., 47, 379–391 (1978).
R. D. Porsholt, A. Bertin, and M. Jalfre, “Behavioral despair in mice: A Primary screening test for antidepressants,” Arch. Int. Pharmacodynamics, 229, 327–336 (1977).
A. Ramos and P. Mormede, “Stress and emotionality: a multidimensional and genetic approach,” Neurosci. Biobehav. Rev., 22, No.1, 33–57 (1998).
R. J. Rogers and C. Cole, “The elevated plus-maze: pharmacology, methodology and ethology,” in: Ethology and Psychopharmacology, S. J. Cooper and C. A. Hendrie (eds.), John Wiley & Sons Ltd., Chichester (1994), pp. 9–44.
K. Yu. Sarkisova, I. S. Midzianovskaia, and M. A. Kulikov, “Depressive-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG/Rij rats with genetic absence epilepsy,” Behav. Brain Res., 144, 211–226 (2003).
T. J. Shors and B. Leuner, “Estrogen-mediated effects on depression and memory formation in females, ” J. Affect. Disord., 74, 85–96 (2003).
W. E. Sternberg and J. F. Mogil, “Genetic and hormonal basis of pain states,” Best Pract. Res. Clinic. Anaesthesiol., 15, No.2, 229–245 (2001).
L. K. Takahashi, “Role of CRF(1) and CRF(2) receptors in fear and anxiety,” Neurosci. Biobehav. Rev., 25, 627–636 (2001).
T. Uz and H. Manev, “Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant mice,” J. Pineal Res., 30, No.3, 166–170 (2001).
J. M. Weiss, P. A. Goodman, B. G. Losito, S. Corrigans, J. M. Charry, and W. H. Bailey, “Behavioral depression produced by an uncontrollable stressor: relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain,” Brain Res. Rev., 3, 167–205 (1981).
G. Yadid, R. Nakash, I. Deri, N. Kinor, I. Gispan, and A. Zangen, “Elucidation of the neurobiology of depression: insights from a novel genetic animal model,” Progr. Neurobiol., 62, 353–378 (2000).
G. Yates, J. Panksepp, S. Ikemoto, E. Nelson, and R. Conner, “Social isolation effects on the ‘behavioral despair’ forced swimming test: effect of age and duration of testing,” Physiol. Behav., 49, 347–353 (1991).
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 90, No. 11, pp. 1324–1336, November, 2004.
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Avgustinovich, D.F., Kovalenko, I.L. Formation of Behavioral Pathology in Female C57BL/6J Mice Exposed to Prolonged Negative Psychoemotional Conditions. Neurosci Behav Physiol 35, 959–967 (2005). https://doi.org/10.1007/s11055-005-0152-8
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DOI: https://doi.org/10.1007/s11055-005-0152-8