Neuroscience and Behavioral Physiology

, Volume 35, Issue 7, pp 737–740 | Cite as

Interaction of Neurons at the Level of Cell Bodies in the Snail CNS. Heterogeneity of the Neuroactive Environment

  • I. A. Chistopol’skii


Experiments on the CNS of snail Lymnaea stagnalis in which a cell isolated from the serotonin cluster PeA was used as a mobile sensor neuron demonstrated the presence of neuroactive factors at the surface of the cellular “cortex” of the pedal ganglion. Apart from the previously known factor serotonin, effective concentrations of a factor suppressing the electrical activity of PeA were found at this site, along with a depolarizing factor which, unlike serotonin, narrowed PeA action potentials. The ability of these factors to control the electrical activity of the sensor neuron demonstrates the possible involvement of chemical agents in the intercellular space of the “cortex” in neuronal signaling.

Key Words

interneuronal signaling isolated neuron Lymnaea stagnalis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    T. L. D’yakonova, “Two types of neurons differing in terms of their plastic properties: studies of ionic mechanisms,” Zh. Vyssh. Nerv. Deyat., 35, No.3, 552–560 (1985).Google Scholar
  2. 2.
    I. A. Chistopol’skii and D. A. Sakharov, “Non-synaptic integration of neuron cell bodies in the snail CNS,” Ros. Fiziol. Zh. im. I. M. Sechenova, 87, No.11, 1540–1547 (2001).Google Scholar
  3. 3.
    I. A. Chistopol’skii and D. A. Sakharov, “Activation of serotoninergic neurons by a metabolic precursor of serotonin: increases in the frequency and duration of action potentials,” Dokl. Ros. Akad. Nauk. 362, No.4, 561–563 (1998).Google Scholar
  4. 4.
    D. Bruns and R. Jahn, “Real-time measurement of transmitter release from single synaptic vesicles,” Nature, 377, No.7, 62–65 (1995).CrossRefPubMedGoogle Scholar
  5. 5.
    G. Chen, P. Gavin, G. Luo, and G. Ewing, “Observation and quantitation of exocytosis from the cell body of a fully developed neuron in Planorbis corneus,” J. Neurosci., 15, No.11, 7747–7755 (1995).PubMedGoogle Scholar
  6. 6.
    C. T. Slade, J. Mills, and W. Winlow, “The neuronal organization of the paired pedal ganglia of Lymnaea stagnalis (L.), Comp. Biochem. Physiol., 69A, No.3, 789–803 (1981).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • I. A. Chistopol’skii
    • 1
  1. 1.Institute of Developmental BiologyRussian Academy of SciencesMoscowRussia

Personalised recommendations