Abstract
Experiments were performed on cats to study the effects of systemic administration of antagonists of dopaminergic transmission on food-related and defensive (an escape response) operant conditioned reflexes acquired on the basis of the innate response of placing the forepaw on a support. Selective blockade of D1 receptors with SCH23390 (0.005–0.1 mg/kg) completely and selective blockade of D2/D3 receptors with raclopride (0.1–0.25 mg/kg) partially suppressed both reflexes. At these doses, both blockers had stronger actions on the defensive conditioned escape reflex than the food-related reflex: SCH23390 had significantly stronger inhibitory effects on both reflexes than raclopride.
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti, Vol. 54, No. 4, pp. 489–494, July–August, 2004.
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Maiorov, V.I., Frolov, A.G. The Effects of Systemic Administration of Selective Antagonists of Dopamine D1 and D2/D3 Receptors on Food-Related and Defensive (escape responses) Conditioned Paw-Placing Responses in Cats. Neurosci Behav Physiol 35, 649–653 (2005). https://doi.org/10.1007/s11055-005-0107-0
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DOI: https://doi.org/10.1007/s11055-005-0107-0