Production of polycaprolactone nanoparticles with low polydispersity index in a tubular recirculating system by using a multifactorial design of experiments

  • Gabriel Jaime Colmenares Roldán
  • Liliana María Agudelo Gomez
  • Jesús Antonio Carlos Cornelio
  • Luis Fernando Rodriguez
  • Rodolfo Pinal
  • Lina Marcela Hoyos Palacio
Research Paper

Abstract

Encapsulation and controlled release of substances using polymeric nanoparticles require that these have a high reproducibility, homogeneity, and control over their properties (diameter and polydispersity), especially when they are to be used in medical, pharmaceutical, or nutritional applications among others. In conventional production systems, it is tough to ensure these characteristics; hence, the cost increases when we try to control these properties. This paper shows a comparison between a recirculating system and the standard nanoprecipitation technique for producing polymeric nanoparticles. In previous investigations, we evaluate the effect of recirculating flow and the ratio between the organic and aqueous phase. For this paper, we evaluated the effect of polymer and surfactant concentrations using a multifactorial design of experiments on the recirculating system and on the standard nanoprecipitation system. The response of the design was the average diameter of the nanoparticles and polydispersity index. Finally, we found that the polymer and surfactant concentrations could change the average diameter and polydispersity index of the nanoparticles obtained. On the other hand, it was found that the effect of the polymer concentration was stronger than the surfactant concentration to reduce the average diameter of the nanoparticles. The results of the present study show that the proposed recirculation system presents a high potential to produce polymer nanoparticles with good morphological characteristics, particle size distributions in the nano range, and with a low polydispersity. The average mean size of nanoparticles of polycaprolactone for the design using the recirculating system was of 61 to 140 nm and the values of polydispersity index PDI for this design were between 0.097 and 0.22, while for the design using the standard nanoprecipitation technique, the obtained diameters were 74 to 176 nm and the polydispersity was between 0.26 and 0.41.

Keywords

Nanoparticles Nanocapsules Nanoprecipitation Polymers Surfactant Nanoencapsulation 

Notes

Acknowledgements

The authors thank the Universidad Pontificia Bolivariana, to Ruta n, and Colciencias for the financial support provided to investigators and Professor Teresa Carvajal and Christopher J. Gilpin of Purdue University for facilitating the characterizations of the samples by DLS and TEM.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Gabriel Jaime Colmenares Roldán
    • 1
    • 2
  • Liliana María Agudelo Gomez
    • 1
    • 2
  • Jesús Antonio Carlos Cornelio
    • 2
  • Luis Fernando Rodriguez
    • 2
  • Rodolfo Pinal
    • 3
  • Lina Marcela Hoyos Palacio
    • 1
    • 2
  1. 1.Grupo de Biología de Sistemas, Escuela de Ciencias de la SaludUniversidad Pontificia BolivarianaMedellínColombia
  2. 2.Grupo de investigación en nanotecnología y materialesNanomatMedellínColombia
  3. 3.Department of Industrial and Physical Pharmacy, College of PharmacyPurdue UniversityWest LafayetteUSA

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