Journal of Nanoparticle Research

, 16:2604 | Cite as

In vitro comparative study of pure hydroxyapatite nanorods and novel polyethylene glycol/graphene oxide/hydroxyapatite nanocomposite

Research Paper


In this work, crystalline hydroxyapatite (HAP) nanorods were first prepared by a simple precipitation method in the presence of a new capping agent based on Schiff base compounds, and then composite of polyethylene glycol (PEG), graphene oxide (GO), and the HAP nanorods was synthesized by freeze-drying method. X-ray diffraction patterns indicated that poor crystalline HAP powders produced in the absence of Schiff base were highly agglomerated. In addition, in vitro bioactivity of the produced HAP nanorods and PEG/GO/HAP nanocomposite was evaluated by soaking the products in simulated body fluid (SBF). The chemical composition of the SBF solutions was analyzed by inductively coupled plasma-optical emission spectrometry, and it was found that more Ca and P were released from the nanocomposite compared to the pure HAP nanorods, indicating high bioactivity of the nanocomposite. In addition, it was observed that the growth of new apatite on the surface of the nano-sized materials increased after immersion for 14 days in the SBF solution.


Hydroxyapatite Composite Bioactivity Nanorod 



Authors are grateful to council of University of Kashan for providing financial support to undertake this work.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Inorganic Chemistry, Faculty of ChemistryUniversity of KashanKashanIslamic Republic of Iran
  2. 2.Institute of Nano Science and Nano TechnologyUniversity of KashanKashanIslamic Republic of Iran

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