Nanoengineered mesoporous silica nanoparticles for smart delivery of doxorubicin

  • Akhilesh Kumar Mishra
  • Himanshu Pandey
  • Vishnu Agarwal
  • Pramod W. Ramteke
  • Avinash C. Pandey
Research Paper


The motive of the at hand exploration was to contrive a proficient innovative pH-responsive nanocarrier designed for an anti-neoplastic agent that not only owns competent loading capacity but also talented to liberate the drug at the specific site. pH sensitive hollow mesoporous silica nanoparticles (~MSN) have been synthesized by sequence of chemical reconstruction with an average particle size of 120 nm. ~MSN reveal noteworthy biocompatibility and efficient drug loading magnitude. Active molecules such as Doxorubicin (DOX) can be stocked and set free from the pore vacuities of ~MSN by tuning the pH of the medium. The loading extent of ~MSN was found up to 81.4 wt% at pH 7.8. At mild acidic pH, DOX is steadily released from the pores of ~MSN. Both, the nitrogen adsorption–desorption isotherms and X-ray diffraction patterns reflects that this system holds remarkable stable mesostructure. Additionally, the outcomes of cytotoxicity assessment further establish the potential of ~MSN as a relevant drug transporter which can be thought over an appealing choice to a polymeric delivery system.


Mesoporous silica nanoparticles Cytotoxicity assays Doxorubicin hydrochloride Drug delivery Nanomedicine 



Authors would like to acknowledge funding support from Department of Science and Technology (DST), Government of India and FA5209-11-P-0160, ITC-PAC Fund Support.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Akhilesh Kumar Mishra
    • 1
    • 2
  • Himanshu Pandey
    • 1
    • 2
  • Vishnu Agarwal
    • 3
  • Pramod W. Ramteke
    • 1
  • Avinash C. Pandey
    • 2
  1. 1.Department of Pharmaceutical Sciences, Faculty of Health SciencesSam Higginbottom Institute of Agriculture, Technology & SciencesAllahabadIndia
  2. 2.Nanotechnology Application Centre, Faculty of ScienceUniversity of AllahabadAllahabadIndia
  3. 3.Department of BiotechnologyMotilal Nehru National Institute of TechnologyAllahabadIndia

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