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Nanoengineered mesoporous silica nanoparticles for smart delivery of doxorubicin

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Abstract

The motive of the at hand exploration was to contrive a proficient innovative pH-responsive nanocarrier designed for an anti-neoplastic agent that not only owns competent loading capacity but also talented to liberate the drug at the specific site. pH sensitive hollow mesoporous silica nanoparticles (~MSN) have been synthesized by sequence of chemical reconstruction with an average particle size of 120 nm. ~MSN reveal noteworthy biocompatibility and efficient drug loading magnitude. Active molecules such as Doxorubicin (DOX) can be stocked and set free from the pore vacuities of ~MSN by tuning the pH of the medium. The loading extent of ~MSN was found up to 81.4 wt% at pH 7.8. At mild acidic pH, DOX is steadily released from the pores of ~MSN. Both, the nitrogen adsorption–desorption isotherms and X-ray diffraction patterns reflects that this system holds remarkable stable mesostructure. Additionally, the outcomes of cytotoxicity assessment further establish the potential of ~MSN as a relevant drug transporter which can be thought over an appealing choice to a polymeric delivery system.

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Acknowledgments

Authors would like to acknowledge funding support from Department of Science and Technology (DST), Government of India and FA5209-11-P-0160, ITC-PAC Fund Support.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad, 211007, India

    Akhilesh Kumar Mishra, Himanshu Pandey & Pramod W. Ramteke

  2. Nanotechnology Application Centre, Faculty of Science, University of Allahabad, Allahabad, 211002, India

    Akhilesh Kumar Mishra, Himanshu Pandey & Avinash C. Pandey

  3. Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, 211004, India

    Vishnu Agarwal

Authors
  1. Akhilesh Kumar Mishra
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  2. Himanshu Pandey
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  3. Vishnu Agarwal
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  4. Pramod W. Ramteke
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  5. Avinash C. Pandey
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Correspondence to Akhilesh Kumar Mishra.

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Mishra, A.K., Pandey, H., Agarwal, V. et al. Nanoengineered mesoporous silica nanoparticles for smart delivery of doxorubicin. J Nanopart Res 16, 2515 (2014). https://doi.org/10.1007/s11051-014-2515-y

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  • DOI: https://doi.org/10.1007/s11051-014-2515-y

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