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Targeted polymeric nanoparticles containing gold nanorods: a therapeutic approach against glioblastoma

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Abstract

Chlorotoxin-targeted polymeric nanoparticles containing entrapped gold nanorods as potential therapeutic agent for glioblastoma multiforme have been developed and evaluated. In first proof of concept experiments, in vitro specific uptake in cancer cells and selective laser-induced cell death have been shown. In vivo studies with optical imaging showed increased retention of targeted NPs in the tumor.

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Authors and Affiliations

  1. Department of Industrial Chemistry “Toso Montanari”, University of Bologna, V. Risorgimento 4, 40136, Bologna, Italy

    Erica Locatelli & Mauro Comes Franchini

  2. Group Biomedical Ultrasound Research, Fraunhofer IBMT, Ensheimer Str. 48, 66386, Sankt Ingbert, Germany

    Wolfgang Bost & Marc Fournelle

  3. Radiochemistry Department, Molecular Imaging Unit, CIC BiomaGUNE, San Sebastián, Guipúzcoa, Spain

    Jordi Llop & Larraitz Gil

  4. Department of Molecular Biotechnology and Health Sciences-Molecular Biotechnology Center and Center of Preclinical Imaging, University of Torino, Via Ribes 5, 10100, Colleretto Giacosa, TO, Italy

    Francesca Arena

  5. Ephoran Multi Imaging Solutions, Srl Via Ribes 5, 10100, Colleretto Giacosa, (TO), Italy

    Vito Lorusso

Authors
  1. Erica Locatelli
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  2. Wolfgang Bost
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  3. Marc Fournelle
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  4. Jordi Llop
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  5. Larraitz Gil
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  6. Francesca Arena
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  7. Vito Lorusso
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  8. Mauro Comes Franchini
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Corresponding author

Correspondence to Mauro Comes Franchini.

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Locatelli, E., Bost, W., Fournelle, M. et al. Targeted polymeric nanoparticles containing gold nanorods: a therapeutic approach against glioblastoma. J Nanopart Res 16, 2304 (2014). https://doi.org/10.1007/s11051-014-2304-7

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  • DOI: https://doi.org/10.1007/s11051-014-2304-7

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