Targeted polymeric nanoparticles containing gold nanorods: a therapeutic approach against glioblastoma

  • Erica Locatelli
  • Wolfgang Bost
  • Marc Fournelle
  • Jordi Llop
  • Larraitz Gil
  • Francesca Arena
  • Vito Lorusso
  • Mauro Comes Franchini
Research Paper


Chlorotoxin-targeted polymeric nanoparticles containing entrapped gold nanorods as potential therapeutic agent for glioblastoma multiforme have been developed and evaluated. In first proof of concept experiments, in vitro specific uptake in cancer cells and selective laser-induced cell death have been shown. In vivo studies with optical imaging showed increased retention of targeted NPs in the tumor.


Nanorods Glioblastoma Brain tumor Chlorotoxin Polymeric micelles Laser irradiation Nanomedicine 

Supplementary material

11051_2014_2304_MOESM1_ESM.doc (4 mb)
Supplementary material 1 (DOC 4120 kb)


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Erica Locatelli
    • 1
  • Wolfgang Bost
    • 2
  • Marc Fournelle
    • 2
  • Jordi Llop
    • 3
  • Larraitz Gil
    • 3
  • Francesca Arena
    • 4
  • Vito Lorusso
    • 5
  • Mauro Comes Franchini
    • 1
  1. 1.Department of Industrial Chemistry “Toso Montanari”University of BolognaBolognaItaly
  2. 2.Group Biomedical Ultrasound ResearchFraunhofer IBMTSankt IngbertGermany
  3. 3.Radiochemistry Department, Molecular Imaging UnitCIC BiomaGUNESan SebastiánSpain
  4. 4.Department of Molecular Biotechnology and Health Sciences-Molecular Biotechnology Center and Center of Preclinical ImagingUniversity of TorinoColleretto GiacosaItaly
  5. 5.Ephoran Multi Imaging SolutionsColleretto GiacosaItaly

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