Click chemistry on the surface of PLGA-b-PEG polymeric nanoparticles: a novel targetable fluorescent imaging nanocarrier
- 514 Downloads
In the quest for biocompatible nanocarriers for biomedical applications, a great deal of effort is put on engineering the nanocomposites surface in order to render them specific to the particular purpose. We developed biocompatible PLGA-b-PEG-based nanoparticles carrying a double functionality (i.e., carboxylic and acetylenic) able to serve as flexible highly selective grafting centers for cancer diagnosis and treatment. As a proof of concept, the nanocarrier was successfully functionalized with a tailored fluorescent molecule by means of click chemistry and with a targeting agent specific for glioblastoma multiforme via amidic bond formation.
KeywordsClick Fluorescein Functionalized polymers Nanochemistry Glioblastoma
The work was partly supported with the funds of SaveMe EU-FP7 project no. CP-IP 263307-2.
- Comes Franchini M, Bonini BF, Camaggi CM, Gentili D, Pession A, Rani M, Strocchi E (2010) Design and synthesis of novel 3,4-disubstituted pyrazoles for nanomedicine applications against malignant gliomas. Eur J Med Chem 45(5):2024–2033Google Scholar
- Hermanson GT (2008) Bioconjugate techniques, 2nd edn. Elsevier, LondonGoogle Scholar
- Huisgen R (1984) 1,3-Dipolar cycloadditions. In: Padwa A (ed) 1,3-Dipolar cycloaddition chemistry. Wiley, New YorkGoogle Scholar
- Opsteen JA, Ayres L, van Hest JCM (2008) Click chemistry in (bio) materials sciences. Mater Matters 3:62–64Google Scholar