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Novel star-type methoxy-poly(ethylene glycol) (PEG)–poly(ε-caprolactone) (PCL) copolymeric nanoparticles for controlled release of curcumin

  • Runliang Feng
  • Wenxia Zhu
  • Zhimei Song
  • Liyan Zhao
  • Guangxi Zhai
Research Paper

Abstract

To improve curcumin’s (CURs) water solubility and release property, a novel star methoxy poly(ethylene glycol)–poly(ε-caprolactone) (MPEG–PCL) copolymer was synthesized through O-alkylation, basic hydrolysis and ring-opening polymerization reaction with MPEG, epichlorohydrin, and ε-caprolactone as raw materials. The structure of the novel copolymer was characterized by 1H NMR, FT-IR, and GPC. The results of FT-IR and differential scanning calorimeter of CUR-loaded nanoparticles (NPs) prepared by dialysis method showed that CUR was successfully encapsulated into the SMP12 copolymeric NPs with 98.2 % of entrapment efficiency, 10.91 % of drug loading, and 88.4 ± 11.2 nm of mean particle diameter in amorphous forms. The dissolubility of nanoparticulate CUR was increased by 1.38 × 105 times over CUR in water. The obtained blank copolymer showed no hemolysis. A sustained CUR release to a total of approximately 56.13 % was discovered from CUR-NPs in 40 % of ethanol saline solution within 72 h on the use of dialysis method. The release behavior fitted the ambiexponent and biphasic kinetics equation. In conclusion, the copolymeric NPs loading CUR might serve as a potential nanocarrier to improve the solubility and release property of CUR.

Keywords

Star MPEG–PCL Nanoparticle Curcumin In vitro release 

Notes

Acknowledgments

This work is supported by the Excellent Young Scientist Award Fund of Shandong Province, China (BS2011CL006) and Scientific Research Fund of University of Jinan (XKY1208).

Conflict of interest

The authors report no conflicts of interest in this work.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Runliang Feng
    • 1
  • Wenxia Zhu
    • 1
    • 2
  • Zhimei Song
    • 1
  • Liyan Zhao
    • 3
  • Guangxi Zhai
    • 4
  1. 1.Department of Pharmaceutical Engineering, School of Medicine and Life SciencesUniversity of Jinan, Shandong Academy of Medical ScienceJinanChina
  2. 2.Shandong Academy of Medical SciencesJinanChina
  3. 3.Department of PharmacyHebei North UniversityZhangjiakouChina
  4. 4.Department of Pharmaceutics, College of PharmacyShandong UniversityJinanChina

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