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Magnetic carbon nanotubes: synthesis by a simple solvothermal process and application in magnetic targeted drug delivery system

  • Deli Xiao
  • Pierre Dramou
  • Hua He
  • Lien Ai Pham-Huy
  • Hui Li
  • Yuyang Yao
  • Chuong Pham-Huy
Research Paper

Abstract

In this study, a new synthesis technique of magnetic multiwall carbon nanotubes (MMWCNTs) was achieved and its application for drug-loading ability was assessed. MMWCNTs were prepared by a simple solvothermal process, which can easily alter the size (100–350 nm), location, and denseness of Fe3O4 beads fixed on MWCNTs as well as the MWCNTs structure via controlling the reaction parameters. The characteristics of MMWCNTs obtained were assessed by scanning electron microscopy, X-ray diffraction, and FTIR. The MMWCNTs were used as a drug carrier to load an anticancer molecule, epirubicin hydrochloride. In addition, its adsorption ability was also evaluated. The Freundlich adsorption model was successfully used to describe the adsorption process. The kinetic data was well fitted with a pseudo-second-order model. Due to its magnetic properties, high adsorption surfaces, and excellent adsorption capacities, the MMWCNTs synthesized in this study are suitable to be applied to a magnetic targeted drug delivery system.

Keywords

Magnetic multiwall carbon nanotubes Solvothermal process Epirubicin hydrochloride Drug delivery Nanomedicine 

Notes

Acknowledgments

This study was supported by Graduate Students Innovative Projects of Jiangsu Province (No. CXZZ11_0812), Zhejiang Provincial Natural Science Foundation of China (Grant No. Y4110235) and the Fundamental Research Funds for the Central Universities (Program No. JKY2011008). The authors are delighted to acknowledge discussions with colleagues in their research group.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Deli Xiao
    • 1
  • Pierre Dramou
    • 1
  • Hua He
    • 1
    • 2
  • Lien Ai Pham-Huy
    • 3
  • Hui Li
    • 1
  • Yuyang Yao
    • 1
  • Chuong Pham-Huy
    • 4
  1. 1.Department of Analytical ChemistryChina Pharmaceutical UniversityNanjingChina
  2. 2.Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of EducationChina Pharmaceutical UniversityNanjingChina
  3. 3.Department of PharmacyStanford University Medical CenterPalo AltoUSA
  4. 4.Faculty of PharmacyUniversity of Paris VParisFrance

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