Magnetic carbon nanotubes: synthesis by a simple solvothermal process and application in magnetic targeted drug delivery system

  • Deli Xiao
  • Pierre Dramou
  • Hua He
  • Lien Ai Pham-Huy
  • Hui Li
  • Yuyang Yao
  • Chuong Pham-Huy
Research Paper


In this study, a new synthesis technique of magnetic multiwall carbon nanotubes (MMWCNTs) was achieved and its application for drug-loading ability was assessed. MMWCNTs were prepared by a simple solvothermal process, which can easily alter the size (100–350 nm), location, and denseness of Fe3O4 beads fixed on MWCNTs as well as the MWCNTs structure via controlling the reaction parameters. The characteristics of MMWCNTs obtained were assessed by scanning electron microscopy, X-ray diffraction, and FTIR. The MMWCNTs were used as a drug carrier to load an anticancer molecule, epirubicin hydrochloride. In addition, its adsorption ability was also evaluated. The Freundlich adsorption model was successfully used to describe the adsorption process. The kinetic data was well fitted with a pseudo-second-order model. Due to its magnetic properties, high adsorption surfaces, and excellent adsorption capacities, the MMWCNTs synthesized in this study are suitable to be applied to a magnetic targeted drug delivery system.


Magnetic multiwall carbon nanotubes Solvothermal process Epirubicin hydrochloride Drug delivery Nanomedicine 



This study was supported by Graduate Students Innovative Projects of Jiangsu Province (No. CXZZ11_0812), Zhejiang Provincial Natural Science Foundation of China (Grant No. Y4110235) and the Fundamental Research Funds for the Central Universities (Program No. JKY2011008). The authors are delighted to acknowledge discussions with colleagues in their research group.


  1. Banfield JF, Welch SA, Zhang H, Ebert TT, Penn RL (2000) Aggregation-based crystal growth and microstructure development in natural iron oxyhydroxide biomineralization products. Science 289:751–754CrossRefGoogle Scholar
  2. Bianco A, Kostarelos K, Prato M (2005) Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol 9:674–679CrossRefGoogle Scholar
  3. Bottini M, Magrini A, Rosato N, Bergamaschi A, Mustelin T (2006) Dispersion of pristine single-walled carbon nanotubes in water by a thiolated organosilane: application in supramolecular nanoassemblies. J Phys Chem B 110:13685–13688CrossRefGoogle Scholar
  4. Cai KY, Luo Z, Hu Y, Chen XY, Liao YJ, Yang L, Deng LH (2009) Magnetically triggered reversible controlled drug delivery from microfabricated polymeric multireservoir devices. Adv Mater 21:4045–4049CrossRefGoogle Scholar
  5. Cao S-W, Zhu Y-J, Chang J (2008) Fe3O4 polyhedral nanoparticles with a high magnetization synthesized in mixed solvent ethylene glycol–water system. New J Chem 32:1526–1530CrossRefGoogle Scholar
  6. Chen Z, Pierre D, He H, Tan S, Pham-Huy C, Hong H, Huang J (2011) Adsorption behavior of epirubicin hydrochloride on carboxylated carbon nanotubes. Int J Pharm 405:153–161CrossRefGoogle Scholar
  7. Correa-Duarte MA, Grzelczak M, Salgueiriño-Maceira V, Giersig M, Liz-Marzán LM, Farle M, Sierazdki K, Diaz R (2005) Alignment of carbon nanotubes under low magnetic fields through attachment of magnetic nanoparticles. J Phys Chem B 109:19060–19063CrossRefGoogle Scholar
  8. Dumortier H, Lacotte S, Pastorin G, Marega R, Wu W, Bonifazi D, Briand J-P, Prato M, Muller S, Bianco A (2006) Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. Nano Lett 6:1522–1528CrossRefGoogle Scholar
  9. Gai QQ, Qu F, Liu ZJ, Dai RJ, Zhang YK (2010) Superparamagnetic lysozyme surface-imprinted polymer prepared by atom transfer radical polymerization and its application for protein separation. J Chromatogr A 1217:5035–5042CrossRefGoogle Scholar
  10. Gao C, Li W, Morimoto H, Nagaoka Y, Maekawa T (2006) Magnetic carbon nanotubes: synthesis by electrostatic self-assembly approach and application in biomanipulations. J Phys Chem B 110:7213–7220CrossRefGoogle Scholar
  11. Gao L, Zhuang J, Nie L, Zhang J, Zhang Y, Gu N, Wang T, Feng J, Yang D, Perrett S, Yan X (2007) Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat Nano 2:577–583CrossRefGoogle Scholar
  12. Georgakilas V, Tzitzios V, Gournis D, Petridis D (2005) Attachment of magnetic nanoparticles on carbon nanotubes and their soluble derivatives. Chem Mater 17:1613–1617CrossRefGoogle Scholar
  13. Graff RA, Swanson TM, Strano MS (2008) Synthesis of nickel–nitrilotriacetic acid coupled single-walled carbon nanotubes for directed self-assembly with polyhistidine-tagged proteins. Chem Mater 20:1824–1829CrossRefGoogle Scholar
  14. He T, Chen D, Jiao X (2004) Controlled synthesis of Co3O4 nanoparticles through oriented aggregation. Chem Mater 16:737–743CrossRefGoogle Scholar
  15. Hong C-Y, You Y-Z, Pan C-Y (2005) Synthesis of water-soluble multiwalled carbon nanotubes with grafted temperature-responsive shells by surface RAFT polymerization. Chem Mater 17:2247–2254CrossRefGoogle Scholar
  16. Jia B, Gao L, Sun J (2007) Self-assembly of magnetite beads along multiwalled carbon nanotubes via a simple hydrothermal process. Carbon 45:1476–1481CrossRefGoogle Scholar
  17. Kim Y, Cho J, Ansari S, Kim H, Dar M, Seo H, Kim G, Lee D, Khang G, Shin H (2006) Immobilization of avidin on the functionalized carbon nanotubes. Synth Met 156:938–943CrossRefGoogle Scholar
  18. Kim IT, Nunnery GA, Jacob K, Schwartz J, Liu X, Tannenbaum R (2010) Synthesis, characterization, and alignment of magnetic carbon nanotubes tethered with maghemite nanoparticles. J Phys Chem C 114:6944–6951CrossRefGoogle Scholar
  19. Korobeinyk AV, Whitby RLD, Niu JJ, Gogotsi Y, Mikhalovsky SV (2011) Rapid assembly of carbon nanotube-based magnetic composites. Mater Chem Phys 128:514–518CrossRefGoogle Scholar
  20. Lijima S (1991) Helical microtubules of graphitic carbon. Nature 354:56–58CrossRefGoogle Scholar
  21. Lin C-L, Lee C-F, Chiu W-Y (2005) Preparation and properties of poly(acrylic acid) oligomer stabilized superparamagnetic ferrofluid. J Colloid Interface Sci 291:411–420CrossRefGoogle Scholar
  22. Liu Z, Sun X, Nakayama-Ratchford N, Dai H (2007) Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery. ACS Nano 1:50–56CrossRefGoogle Scholar
  23. Lu W, Shen Y, Xie A, Zhang W (2010) Green synthesis and characterization of superparamagnetic Fe3O4 nanoparticles. J Magn Magn Mater 322:1828–1833CrossRefGoogle Scholar
  24. Nam J-M, Thaxton CS, Mirkin CA (2003) Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science 301:1884–1886CrossRefGoogle Scholar
  25. Pantarotto D, Singh R, McCarthy D, Erhardt M, Briand JP, Prato M, Kostarelos K, Bianco A (2004) Angew Chem Int Ed 43:5242CrossRefGoogle Scholar
  26. Pavani R, Vinay K (2011) Carbon nanotubes and pharmaceutical applications. Int Res J Pharm 2:15–21Google Scholar
  27. Shen W, Chen X, Shi Y, Shi M, Chen H (2012) Synthesis of monodisperse and single-crystal Fe3O4 hollow spheres by a solvothermal approach. Mater Chem Phys 132:987–992CrossRefGoogle Scholar
  28. Sun S, Wang A (2006) Adsorption kinetics of Cu(II) ions using N,O-carboxymethyl-chitosan. J Hazard Mater 131:103–111CrossRefGoogle Scholar
  29. Sun S, Murray CB, Weller D, Folks L, Moser A (2000) Monodisperse FePt nanoparticles and ferromagnetic FePt nanocrystal superlattices. Science 287:1989–1992CrossRefGoogle Scholar
  30. Wang HF, Wang J, Deng XY, Sun HF, Shi ZJ, Gu ZN, Liu YF, Zhao YL (2004) J Nanosci Nanotechnol 4:1019CrossRefGoogle Scholar
  31. Xuan S, Wang Y-XJ, Yu JC, Cham-Fai LK (2009) Tuning the grain size and particle size of superparamagnetic Fe3O4 microparticles. Chem Mater 21:5079–5087CrossRefGoogle Scholar
  32. Yan XM, Shi BY, Lu JJ, Feng CH, Wang DS, Tang HX (2008) Adsorption and desorption of atrazine on carbon nanotubes. J Colloid Interface Sci 321:30–38CrossRefGoogle Scholar
  33. Yang D, Yang F, Hu J, Long J, Wang C, Fu D, Ni Q (2009) Hydrophilic multi-walled carbon nanotubes decorated with magnetite nanoparticles as lymphatic targeted drug delivery vehicles. Chem Commun 7(29):4447–4449Google Scholar
  34. Zhang X, Meng L, Lu Q, Fei Z, Dyson PJ (2009) Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes. Biomaterials 30:6041–6047CrossRefGoogle Scholar
  35. Zhu HY, Jiang R, Xiao L, Zeng GM (2010) Preparation, characterization, adsorption kinetics and thermodynamics of novel magnetic chitosan enwrapping nanosized γ-Fe2O3 and multi-walled carbon nanotubes with enhanced adsorption properties for methyl orange. Bioresour Technol 101:5063–5069CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Deli Xiao
    • 1
  • Pierre Dramou
    • 1
  • Hua He
    • 1
    • 2
  • Lien Ai Pham-Huy
    • 3
  • Hui Li
    • 1
  • Yuyang Yao
    • 1
  • Chuong Pham-Huy
    • 4
  1. 1.Department of Analytical ChemistryChina Pharmaceutical UniversityNanjingChina
  2. 2.Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of EducationChina Pharmaceutical UniversityNanjingChina
  3. 3.Department of PharmacyStanford University Medical CenterPalo AltoUSA
  4. 4.Faculty of PharmacyUniversity of Paris VParisFrance

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