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Bivalent alkyne-bisphosphonate as clickable and solid anchor to elaborate multifunctional iron oxide nanoparticles with microwave enhancement

Abstract

We report the elaboration of clickable superparamagnetic nanoparticles that act as a scaffold for further modifications by click chemistry. This nano platform is easily obtained by coating iron oxide nanoparticle γ-Fe2O3, with a new bifunctional molecule (1-hydroxy-1-phosphonopent-4-ynyl)phosphonic acid (HMBPyne). The HMBP and the alkyne functions act respectively as anchoring surface group and click chemistry functionality. We evaluate the functionalization of this new “clickable” nanoplateform using Huisgen 1,3-cycloaddition as model reaction and demonstrate the potential of microwave irradiation to increase the grafting yield. The effectiveness of click chemistry for the modification of mNPs is explored with a diverse array of functional species.

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Acknowledgments

The authors thank the Magnisense Corporation for providing a MIAplex Reader. The authors also thank N. Lièvre (UFR SMBH, Université Paris 13, Bobigny, France) for TEM images and I. Milosevic (UMR 7244 CNRS, Université Paris 13, Bobigny, France) for her assistance concerning XRD.

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Correspondence to Erwann Guénin.

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Guénin, E., Hardouin, J., Lalatonne, Y. et al. Bivalent alkyne-bisphosphonate as clickable and solid anchor to elaborate multifunctional iron oxide nanoparticles with microwave enhancement. J Nanopart Res 14, 965 (2012). https://doi.org/10.1007/s11051-012-0965-7

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  • DOI: https://doi.org/10.1007/s11051-012-0965-7

Keywords

  • Nanoparticle functionalization
  • Click chemistry
  • Huisgen 1,3-cycloaddition
  • Microwave
  • Iron oxide nanoparticle