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Effects of surfactants on properties of polymer-coated magnetic nanoparticles for drug delivery application

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Abstract

The objective of this research was to compare the effects of two different surfactants on the physicochemical properties of thermo-responsive poly(N-isopropylacrylamide-acrylamide-allylamine) (PNIPAAm-AAm-AH)-coated magnetic nanoparticles (MNPs). Sodium dodecyl sulfate (SDS) as a commonly used surfactant in nanoparticle formulation process and Pluronic F127 as an FDA approved material were used as surfactants to synthesize PNIPAAm-AAm-AH-coated MNPs (PMNPs). The properties of PMNPs synthesized using SDS (PMNPs-SDS) and PF127 (PMNPs-PF127) were compared in terms of size, polydispersity, surface charge, drug loading efficiency, drug release profile, biocompatibility, cellular uptake, and ligand conjugation efficiency. These nanoparticles had a stable core–shell structure with about a 100-nm diameter and were superparamagnetic in behavior with no difference in the magnetic properties in both types of nanoparticles. In vitro cell studies showed that PMNPs-PF127 were more cytocompatible and taken up more by prostate cancer cells than that of PMNPs-SDS. Cells internalized with these nanoparticles generated a dark negative contrast in agarose phantoms for magnetic resonance imaging. Furthermore, a higher doxorubicin release at 40 °C was observed from PMNPs-PF127, and the released drugs were pharmacologically active in killing cancer cells. Finally, surfactant type did not affect the conjugation efficiency to the nanoparticles when folic acid was used as a targeting ligand model. These results indicate that PF127 might be a better surfactant to form polymer-coated magnetic nanoparticles for targeted and controlled drug delivery.

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Acknowledgements

TEM was performed at the University of Texas Southwestern Medical Center Molecular and Cellular Imaging Facility. This research was supported by the Department of Defense (Grant No.W81XWH-09-1-0313).

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Authors and Affiliations

  1. Department of Bioengineering, University of Texas at Arlington, 500 UTA Blvd, ERB 241, Arlington, TX, 76019, USA

    Nesreen Alzoghoul Alsmadi, Aniket S. Wadajkar & Kytai T. Nguyen

  2. Department of Biomedical Engineering, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390, USA

    Nesreen Alzoghoul Alsmadi, Aniket S. Wadajkar & Kytai T. Nguyen

  3. Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390, USA

    Weina Cui

Authors
  1. Nesreen Alzoghoul Alsmadi
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  2. Aniket S. Wadajkar
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  3. Weina Cui
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  4. Kytai T. Nguyen
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Corresponding author

Correspondence to Kytai T. Nguyen.

Additional information

N. A. Alsmadi and A. S. Wadajkar contributed equally to this study.

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Alsmadi, N.A., Wadajkar, A.S., Cui, W. et al. Effects of surfactants on properties of polymer-coated magnetic nanoparticles for drug delivery application. J Nanopart Res 13, 7177–7186 (2011). https://doi.org/10.1007/s11051-011-0632-4

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  • DOI: https://doi.org/10.1007/s11051-011-0632-4

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