A feasible method of improving the quantum yield of CdTe/CdS quantum dots by the first heating–cooling cycle and their application in cancer cell recognition
- 148 Downloads
In this article, water-soluble CdTe/CdS quantum dots (QDs) were synthesized in aqueous solution with captosuccinic acid as stabilizer. The absorption and fluorescence spectra showed that the as-prepared QDs had good optical properties. It was observed that the quantum yield (QY) of QDs was greatly increased after a heating–cooling cycle (from 22 to 41%). Then, the QDs were used to prepare fluorescent probes. The experiment results showed that the transferrin (Tf) could conjugate to QDs effectively and the HepG2 cells could be recognized successfully. This study is of great significance for the preparation of high-quality QDs and their applications in life science.
KeywordsQuantum dots Temperature Fluorescence Bioprobes Cell recognition Nanomedicine
This study was supported by the National Natural Science Foundation of China (Grant No. 30670553), National High Technology Research and Development Program of China (863 Program: 2007AA10Z328). We also thank Analytical and Testing Center (HUST) for the help of measurement. This study was also supported by the Graduate Innovation Fund of Huazhong University of Science and Technology (HF05222007170).
- Gardner HC, Gallardo DE, Bertoni C, Dunn S (2006) Temperature shifted photoluminescence in CdTe nanocrystals. Proc SPIE 6195:61950N1–61950N8Google Scholar
- Talapin DV, Rogach AL, Shevchenko EV, Kornowski A, Haase M, Weller H (2002) Dynamic distribution of growth rates within the ensembles of colloidal II–VI and III–V semiconductor nanocrystals as a factor governing their photoluminescence efficiency. J Am Chem Soc 124:5782–5790CrossRefPubMedGoogle Scholar
- Yang MM, Yang P, Zhang LW (1994) Study on the interaction of protein and caffeic acid by fluorescence method. Chin Sci Bull 39:31–35Google Scholar