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Effect of chain length and electrical charge on properties of ammonium-bearing bisphosphonate-coated superparamagnetic iron oxide nanoparticles: formulation and physicochemical studies

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Abstract

Bisphosphonates BP molecules have shown to be efficient for coating superparamagnetic iron oxide particles. In order to clarify the respective roles of electrical charge and the length of the molecules, bisphosphonates with one or two ammonium moieties with an intermediate aliphatic group of 3, 5 or 7 carbons were synthesized and iron oxide nanoparticles coated. The evaluation on their iron core properties was made by transmission electron microscopy (TEM), nuclear magnetic relaxation dispersion (NMRD) profiles and Mössbauer spectra. The core size is close to 5 nm, with a global superparamagnetic behaviour modified by a paramagnetic Fe-based layer, probably due to surface crystal alteration. The hydrodynamic sizes increase slightly with aliphatic chain length (from 9.8 to 18.6 nm). The presence of one or two ammonium group(s) lowers the negative electrophoretic mobility up to bear zero values but reduces their colloidal stability. These BP-coated iron oxide nanoparticles are promising Magnetic Resonance Imaging (MRI) contrast agents.

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Acknowledgements

Financial support provided by ‘Collectivités territoriales’ of Angers is gratefully acknowledged. The work of NMRD profiles was supported by the FNRS and the ARC Program 05/10-335 of the French Community of Belgium. The support and sponsorship concerted by COST Action D38 and the EMIL project are kindly acknowledged.

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Authors and Affiliations

  1. Inserm U646, Université d’Angers, 10 rue Bocquel, 49100, Angers, France

    Ali Karimi, François Hindré & Jean-Jacques Le Jeune

  2. Centre Hospitalier Annemasse-Bonneville, 64 avenue de Genève, 74130, Bonneville, France

    Benoit Denizot

  3. Service Commun d’Imagerie et d’Analyses Microscopiques, Université d’Angers, rue Haute de Reculée, 49045, Angers Cedex 01, France

    Robert Filmon

  4. Laboratoire de Physique de I’Etat Condensé UMR 6087, Université du Mans, 72085, Le Mans Cedex, France

    Jean-Marc Greneche

  5. Department of General, Organic and Biochemical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut, Avenue du Champs de Mars 24, 7000, Mons, Belgium

    Sophie Laurent

  6. Institut de Physique et Chimie des Matériaux de Strasbourg, UMR CNRS-ULP 7504, 23 rue du Loess, BP43, 67034, Strasbourg Cedex 2, France

    T. Jean Daou

  7. Laboratoire de Matériaux à Porosité Contrôlée, UMR CNRS 7016, Université de Haute Alsace, 3 rue Alfred Werner, 68093, Mulhouse Cedex, France

    Sylvie Begin-Colin

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  1. Ali Karimi
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  2. Benoit Denizot
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  3. François Hindré
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  4. Robert Filmon
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  5. Jean-Marc Greneche
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  6. Sophie Laurent
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  7. T. Jean Daou
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  8. Sylvie Begin-Colin
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  9. Jean-Jacques Le Jeune
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Correspondence to Benoit Denizot.

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Karimi, A., Denizot, B., Hindré, F. et al. Effect of chain length and electrical charge on properties of ammonium-bearing bisphosphonate-coated superparamagnetic iron oxide nanoparticles: formulation and physicochemical studies. J Nanopart Res 12, 1239–1248 (2010). https://doi.org/10.1007/s11051-009-9815-7

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  • DOI: https://doi.org/10.1007/s11051-009-9815-7

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