Multi-functionalized single-walled carbon nanotubes as tumor cell targeting biological transporters
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Multi-functionalized single walled carbon nanotubes (SWNTs) were prepared and applied as tumor cell targeting biological transporters. A positive charge was introduced on SWNTs to get high loading efficiency of fluorescein (FAM) labeled short double strands DNA (20 base pairs). The SWNTs were encapsulated with the folic acid modified phospholipids for active targeting into tumor cell. The tumor cell-targeting properties of these multi-functionalized SWNTs were investigated by active targeting into mouse ovarian surface epithelial cells. The experimental results show that these multi-functionalized SWNTs have good tumor cell targeting property.
KeywordsSingle-walled carbon nanotubes Tumor Targeted drugs Nanomedicine
We gratefully acknowledge the financial support from MOE (#20040055020) and NSF founding of Tianjin city (#07JCYBJC01700).
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