Journal of Nanoparticle Research

, Volume 10, Issue 3, pp 437–448 | Cite as

The characters of self-assembly core/shell nanoparticles of amphiphilic hyperbranched polyethers as drug carriers

  • Wan Ajun
  • Kou Yuxia
Research Paper


The characters of self-assembly core/shell nanoparticles of amphiphilic hyperbranched polyethers (HP-g-PEO) as drug carriers were investigated. The HP-g-PEO consisting of hydrophobic HP-g-PEO core and hydrophilic poly(ethylene glycol) arms was prepared by the cation ring-opening polymerization. A series of HP-g-PEO samples with different degree of branching (DB) were synthesized under various reaction temperatures. Nanoparticles (NP) were obtained by self-assembly of HP-g-PEO in aqueous media. The structure of resulting HP-g-PEO was characterized by IR, 13CNMR and GPC. Dynamic light scattering and transmission electron microscopy were applied to characterize the sizes and size distributions of NP. The results demonstrated that the mean diameters of NP were less than 100 nm, which exhibited uniform spherical formations and narrow size distributions. Using hydrophobic drug Probucol (PRO) as model drug, the particle sizes of drug loaded NP were larger than relative blank NP. The drug loading efficiency (LE) and incorporation efficiency (IE) of these NP were achieved to 35 and 89%, respectively. The in vitro release of PRO from the NP exhibited a sustained release and the cumulative drugs released for more than 600 h. The most important factor to affect drug release was the value of DB of HP-g-PEO. With the DB of HP-g-PEO increasing, the size and size distribution of NP decreased as well as the release rate. However, the small DB was beneficial to the LE of NP. Nanoparticle size and size distribution, LE, IE, and drug release rate were slightly affected by the initial solution concentration of polyethers. The co-incorporated hydrophilic drug had influence slightly on the release of drug from drug loaded NP. The results of in vitro drug release suggested that the core/shell NP performed good controlled release behaviors with potential practice as novelty drug delivery vehicles.


Amphiphilic hyperbranched polyether Nanoparticle Probucol Self-assembly Drug delivery Nanomedicine 



This work is supported by the National Natural Science Foundation of China (Grant No. 20676079, 20376045), and partly supported by the Nanometer Technology Program of Science and Technology Committee of Shanghai (0452 nm037).


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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  1. 1.College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghaiChina

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