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Disfiguring Mucor irregularis Infection Cured by Amphotericin B and Itraconazole: A Case Report and Treatment Experience

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Abstract

We report a case of primary cutaneous mucormycosis caused by Mucor irregularis. A 52-year-old male farmer was presented to our hospital with a history of progressive nodule and plaque with ulceration on the face for two and a half years. Broad, aseptate hyphae were seen in direct KOH examination and biopsy. Fungal culture showed light yellow filamentous colonies. The rRNA sequencing revealed M. irregularis was the responsible fungus. Amphotericin B in gradually increasing dose and itraconazole were administered. When the cumulative dose of amphotericin B was 1500 mg, the skin lesion improved significantly with remaining scars on the face. Then, the patient received sequential oral itraconazole treatment for 8 months. There was no recurrence up to now through follow-ups.

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Authors and Affiliations

  1. Department of Dermatology, Peking University First Hospital, Beijing, China

    Lin-wei Wei, Ying-gai Song & Jin Yu

  2. Research Center for Medical Mycology, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Diseases, Beijing, China

    Lin-wei Wei, Ying-gai Song & Jin Yu

  3. Department of Dermatology, Qingdao No. 6. People’s Hospital, 9th Fushun Street, Shibei District, Qingdao, China

    Hong Wang

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  1. Lin-wei Wei
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  2. Hong Wang
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  3. Ying-gai Song
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  4. Jin Yu
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Correspondence to Jin Yu.

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Informed consent for case report and image report was obtained from the patient.

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Handling editor: Cunwei Cao.

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Wei, Lw., Wang, H., Song, Yg. et al. Disfiguring Mucor irregularis Infection Cured by Amphotericin B and Itraconazole: A Case Report and Treatment Experience. Mycopathologia 184, 677–682 (2019). https://doi.org/10.1007/s11046-019-00380-5

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  • DOI: https://doi.org/10.1007/s11046-019-00380-5

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