Abstract
Disseminated phaeohyphomycosis is an extremely rare clinical syndrome, especially in a host without apparent immunological defect. Here, we report a case of disseminated phaeohyphomycosis in a 22-year-old previously healthy man who showed nonmassive hemoptysis from diffuse lung nodules and cavities, together with a hard palate ulcer and generalized subcutaneous nodules. Histopathology, cultures and subsequent molecular assay from two different sites confirmed Curvularia tuberculata infection. The patient was successfully treated with amphotericin B and itraconazole.
Similar content being viewed by others
References
Revankar SG, Sutton DA. Melanized fungi in human disease. Clin Microbiol Rev. 2010;23(4):884–928.
Ajello L, Georg LK, Steigbigel RT, Wang CJ. A case of phaeohyphomycosis caused by a new species of Phialophora. Mycologia. 1974;66:490–8.
Revankar SG. Phaeohyphomycosis. Infect Dis Clin N Am. 2006;20:609–20.
Madrid H, da Cunha KC, Gene J, Dijksterhuis J, Cano J, Sutton DA, et al. Novel Curvularia species from clinical specimens. Persoonia. 2014;33:48–60.
Jain B. Two new species of Curvularia. Trans Br Mycol Soc. 1962;45:539–44.
Manamgoda DS, Cai L, Bahkali AH, Chukeatirote E, Hyde KD. Cochliobolus: an overview and current status of species. Fungal Divers. 2011;51:3–42.
Manamgoda DS, Rossman AY, Castlebury LA, Chukeatirote E, Hyde K. A taxonomic and phylogenetic re-appraisal of the genus Curvularia (Pleosporaceae): human and plant pathogens. Phytotaxa. 2015;212:24.
Revankar SG, Patterson JE, Sutton DA, Pullen R, Rinaldi MG. Disseminated phaeohyphomycosis: review of an emerging mycosis. Clin Infect Dis. 2002;34:467–76.
Tessari G, Forni A, Ferretto R, Solbiati M, Faggian G, Mazzucco A, et al. Lethal systemic dissemination from a cutaneous infection due to Curvularia lunata in a heart transplant recipient. J Eur Acad Dermatol Venereol. 2003;17:440–2.
Sivanesan A. The teleomorph of Curvularia tuberculata. Trans Br Mycol Soc. 1985;84:548–51.
Chowdhary A, Meis JF, Guarro J, de Hoog GS, Kathuria S, Arendrup MC, et al. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi. Clin Microbiol Infect. 2014;20(Suppl 3):47–75.
Shelton BG, Kirkland KH, Flanders WD, Morris GK. Profiles of airborne fungi in buildings and outdoor environments in the United States. Appl Environ Microbiol. 2002;68:1743–53.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflicts of interest. The authors alone are responsible for the content and writing of this paper.
Additional information
Handling Editor: Anne D. van Diepeningen.
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Vasikasin, V., Nasomsong, W., Srisuttiyakorn, C. et al. Disseminated Phaeohyphomycosis Caused by Curvularia tuberculata in a Previously Healthy Man. Mycopathologia 184, 321–325 (2019). https://doi.org/10.1007/s11046-019-00323-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11046-019-00323-0