, Volume 183, Issue 5, pp 829–834 | Cite as

Successful Sequential Treatment with Itraconazole and ALA-PDT for Cutaneous Granuloma by Candida albicans: A Case Report and Literature Review

  • Qing Cai
  • Lian-juan Yang
  • Jia Chen
  • Hong Yang
  • Zhi-qin Gao
  • Xiu-li Wang
Original Paper


Photodynamic therapy (PDT) is a process that combines a photosensitizing drug and light and promotes phototoxic responses in target cells, mainly via oxidative damage. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and deep mycoses. We present a case of a cutaneous granuloma caused by C. albicans treated with 5-aminolevulinic acid (ALA)-PDT. A 64-year-old man presented with two plaques on his right hand and wrist for 2 years. The diagnosis was made based on histopathology, mycology, and molecular identification of paraffin-embedded tissues. The patient was treated with itraconazole for 1 month and two sessions of ALA-PDT. After 2 months of follow-up, the patient was cured and has not experienced any recurrence to date. ALA-PDT was well tolerated in this patient with little pain. In general, application of PDT in mycoses is safe and effective in most cases. ALA-PDT is a good choice for inactivation of C. albicans.


ALA-PDT Candida albicans Infectious granuloma 



We would like to thank our colleagues from the Institute of Photomedicine located in our hospital.


This work was supported by the National Natural Science Foundation of China (Grant Number 81573063) (General program), the National Natural Science Foundation of China (Grant Number 81602770) (Youth program), and the Project of Shanghai Municipal Commission of Health and Family Planning (Grant Numbers 20140388, 20164Y0248).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of MycologyShanghai Dermatology HospitalShanghaiChina
  2. 2.Department of PathologyShanghai Dermatology HospitalShanghaiChina
  3. 3.Institute of PhotomedicineShanghai Dermatology HospitalShanghaiChina

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