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Liposomal Amphotericin B as Monotherapy in Relapsed Coccidioidal Meningitis

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Abstract

Coccidioidal meningitis remains a difficult clinical problem, and despite life-long therapy with triazole antifungals, relapses of disease and medication intolerance occur necessitating salvage treatment. We report two patients with recurrent coccidioidal meningitis who improved following a 2-week course of liposomal amphotericin B monotherapy and discuss potential advantages of this treatment option.

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Funding

Departmental funds were used for this project.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, 4150 V Street, Suite G500, Sacramento, CA, 95817, USA

    Ethan R. Stewart, Matthew L. Eldridge, Stuart H. Cohen & George R. Thompson III

  2. Department of Medical Microbiology and Immunology, Department of Medicine, Division of Infectious Diseases, University of California – Davis, One Shields Ave, Tupper Hall, Rm 3138, Davis, CA, 95616, USA

    Ian McHardy & George R. Thompson III

Authors
  1. Ethan R. Stewart
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  2. Matthew L. Eldridge
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  3. Ian McHardy
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  4. Stuart H. Cohen
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  5. George R. Thompson III
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Correspondence to George R. Thompson III.

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Stewart, E.R., Eldridge, M.L., McHardy, I. et al. Liposomal Amphotericin B as Monotherapy in Relapsed Coccidioidal Meningitis. Mycopathologia 183, 619–622 (2018). https://doi.org/10.1007/s11046-017-0240-7

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  • DOI: https://doi.org/10.1007/s11046-017-0240-7

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