Study on the Clinical Features and Prognosis of Penicilliosis marneffei Without Human Immunodeficiency Virus Infection
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To improve the diagnosis and treatment of Penicilliosis marneffei without human immunodeficiency virus infection.
Analyze and review the clinical features, diagnosis and treatment of six cases of P. marneffei without human immunodeficiency virus infection at The First Affiliated Hospital of Fujian Medical University.
Two cases were diagnosed in the ENT Department, three cases in the respiratory department and one case in the dermatological department. Penicillium marneffei infection was confirmed by sputum culture, blood culture and tissue biopsy. After definite diagnosis, one refused further treatment, and others showed significant improvement.
Penicilliosis marneffei is insidious onset and easy to be escaped and misdiagnosed. To achieve early diagnosis and appropriate treatment, doubtful cases should be alerted for the diagnoses as P. marneffei.
KeywordsPenicillium marneffei Penicilliosis marneffei Pneumocystis pneumonia Antimycotic chemotherapy
Authors thank professor Lin Qi-chang, Department of Respiration, the First Affiliated Hospital of Fujian Medical University, for his kind of offering the cases of respiratory department. We also thank our colleagues of clinical laboratory for their assistance of fungal identification.
Compliance with Ethical Standards
Conflict of interest
The research has no conflicts of interest.
The research was compliance with ethical standards, and all the patients involved were informed consent.
- 3.Xie Y, Li Y, Hu C, et al. The analysis of risk factors and the immune status in Penicillium marneffei in patients without human immunodeficiency virus infection. Chin Mycol. 2016;11(3):174–7.Google Scholar
- 4.Yulan L, Bin Y, Yongxu J, et al. A case report of disseminated Penicillium marneffei without HIV infection. Int J Lab Med. 2012;33(10):1196–9.Google Scholar
- 7.Lu ZH, Liu HR, Xie XL, et al. Infection of Penicillium marneffei. [Zhonghua bing li xue za zhi] Chin J Pathol. 2004;33(6):536–40 (in Chinese).Google Scholar
- 9.Mo Z. Two Penicillium marneffei infant with HIV-negative, cases report and literature review[J]. J Youjiang Med Univ Natl. 2015;37(5):737–9.Google Scholar
- 10.Su X, Zhang N, Liu C, et al. Disseminated Penwillium marneffei infection in immunocompetent patients: one case report and literature review. Chin J Respir Crit Care Med. 2013;12(3):244–8.Google Scholar
- 13.Li L, Tang X, Cai W. The clinical research of 101 AIDS combined with Penicilliosis marneffei. Chin AIDS. 2008;14(1):12–4.Google Scholar
- 14.Li HJ, Zhang YJ, et al. CT manifestation of Penicillium marneffei pneumonia in AIDS patients. Fang she xue shi jian Radiol Pract. 2009;24(9):952–4.Google Scholar
- 15.Bo L, Ping F. Research progress of Penicilliosis marneffei. Dermatol Venereol. 2010;3(1):26–8.Google Scholar
- 17.Wanshan C, Xiaoping T, Yecheng L, et al. In vitro susceptibilities of 5 antifungal agents against 52 strains of Penicillium marneffei. Chin J Infect Dis. 2008;26(3):143–5.Google Scholar
- 18.Ye R, Song W, Qiu X, et al. Analysis of fungus infection and drug sensitivity in AIDS patients. Guangdong Med. 2007;28(5):783–5.Google Scholar
- 19.Zhang Q, Liang L, Cao C, et al. Effects of amphotericin B and voriconazole on ultrastructure of a clinical isolate of Penicillium marneffei. Chin J Dermatol. 2015;8:572–5.Google Scholar
- 20.Xie L, Wang J, Zhang J, et al. Identification and in vitro antifungal susceptibility of Penicillium marneffei in yeast phase. Chin J Infect Control. 2016;15(12):934–8.Google Scholar
- 21.Cristina M, Patriza P, Alessanda G, et al. Discontinuation of primary prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus type-1 infections: the charges in opportunistic prophylaxis study. Infect Dis. 2000;18(5):1635–42.Google Scholar