Mycopathologia

, Volume 183, Issue 3, pp 551–558 | Cite as

Study on the Clinical Features and Prognosis of Penicilliosis marneffei Without Human Immunodeficiency Virus Infection

  • Ying-ge Wang
  • Jin-mei Cheng
  • Hai-bo Ding
  • Xi Lin
  • Guo-hao Chen
  • Mei Zhou
  • Sheng-nan Ye
Original Paper
  • 92 Downloads

Abstract

Objective

To improve the diagnosis and treatment of Penicilliosis marneffei without human immunodeficiency virus infection.

Methods

Analyze and review the clinical features, diagnosis and treatment of six cases of P. marneffei without human immunodeficiency virus infection at The First Affiliated Hospital of Fujian Medical University.

Results

Two cases were diagnosed in the ENT Department, three cases in the respiratory department and one case in the dermatological department. Penicillium marneffei infection was confirmed by sputum culture, blood culture and tissue biopsy. After definite diagnosis, one refused further treatment, and others showed significant improvement.

Conclusion

Penicilliosis marneffei is insidious onset and easy to be escaped and misdiagnosed. To achieve early diagnosis and appropriate treatment, doubtful cases should be alerted for the diagnoses as P. marneffei.

Keywords

Penicillium marneffei Penicilliosis marneffei Pneumocystis pneumonia Antimycotic chemotherapy 

Notes

Acknowledgements

Authors thank professor Lin Qi-chang, Department of Respiration, the First Affiliated Hospital of Fujian Medical University, for his kind of offering the cases of respiratory department. We also thank our colleagues of clinical laboratory for their assistance of fungal identification.

Compliance with Ethical Standards

Conflict of interest

The research has no conflicts of interest.

Ethical Standard

The research was compliance with ethical standards, and all the patients involved were informed consent.

References

  1. 1.
    Hu Y, Zhang J, Li X, et al. Penicillium marneffei infection: an emerging disease in mainland China. Mycopathologia. 2013;175(1–2):57–67.CrossRefPubMedGoogle Scholar
  2. 2.
    Devi KR, Singh LR, Rajkumari R, et al. Penicillium marneffei—an indicator disease of AIDS: a case report. Indian J Pathol Microbiol. 2007;50(3):674–6.PubMedGoogle Scholar
  3. 3.
    Xie Y, Li Y, Hu C, et al. The analysis of risk factors and the immune status in Penicillium marneffei in patients without human immunodeficiency virus infection. Chin Mycol. 2016;11(3):174–7.Google Scholar
  4. 4.
    Yulan L, Bin Y, Yongxu J, et al. A case report of disseminated Penicillium marneffei without HIV infection. Int J Lab Med. 2012;33(10):1196–9.Google Scholar
  5. 5.
    Cooper CR Jr, Haycocks NG. Penicillium marneffei: an insurgent species among the penicillin. Eukaryot Microbiol. 2000;47(1):24–8.CrossRefGoogle Scholar
  6. 6.
    Tsui WM, Ma KF, Tsang DN. Disseminated Penicillium marneffei infection in HIV-infected subject. Histopathology. 1992;20:287–93.CrossRefPubMedGoogle Scholar
  7. 7.
    Lu ZH, Liu HR, Xie XL, et al. Infection of Penicillium marneffei. [Zhonghua bing li xue za zhi] Chin J Pathol. 2004;33(6):536–40 (in Chinese).Google Scholar
  8. 8.
    Vanittanakom N, Cooper CR Jr, Fisher MC, et al. Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects. Clin Microbiol Rev. 2006;19(1):95–110.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Mo Z. Two Penicillium marneffei infant with HIV-negative, cases report and literature review[J]. J Youjiang Med Univ Natl. 2015;37(5):737–9.Google Scholar
  10. 10.
    Su X, Zhang N, Liu C, et al. Disseminated Penwillium marneffei infection in immunocompetent patients: one case report and literature review. Chin J Respir Crit Care Med. 2013;12(3):244–8.Google Scholar
  11. 11.
    Kawila R, Chaiwarith R, Supparatpinyo K. Clinical and laboratory characteristics of Penicilliosis marneffei among patients with and without HIV infection in Northern Thailand: a retrospective study. BMC Infect Dis. 2013;13:464.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Qiu Y, Liao H, Zhang J, et al. Differences in clinical characteristics and prognosis of Penicilliosis among HIV-negative patients with or without underlying disease in Southern China: a retrospective study. BMC Infect Dis. 2015;15:525.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Li L, Tang X, Cai W. The clinical research of 101 AIDS combined with Penicilliosis marneffei. Chin AIDS. 2008;14(1):12–4.Google Scholar
  14. 14.
    Li HJ, Zhang YJ, et al. CT manifestation of Penicillium marneffei pneumonia in AIDS patients. Fang she xue shi jian Radiol Pract. 2009;24(9):952–4.Google Scholar
  15. 15.
    Bo L, Ping F. Research progress of Penicilliosis marneffei. Dermatol Venereol. 2010;3(1):26–8.Google Scholar
  16. 16.
    Liyan X, Changming L, Xianyi Z, et al. Fifteen cases of penicilliosis in Guangdong, China. Mycopathologia. 2004;158(2):151–5.CrossRefPubMedGoogle Scholar
  17. 17.
    Wanshan C, Xiaoping T, Yecheng L, et al. In vitro susceptibilities of 5 antifungal agents against 52 strains of Penicillium marneffei. Chin J Infect Dis. 2008;26(3):143–5.Google Scholar
  18. 18.
    Ye R, Song W, Qiu X, et al. Analysis of fungus infection and drug sensitivity in AIDS patients. Guangdong Med. 2007;28(5):783–5.Google Scholar
  19. 19.
    Zhang Q, Liang L, Cao C, et al. Effects of amphotericin B and voriconazole on ultrastructure of a clinical isolate of Penicillium marneffei. Chin J Dermatol. 2015;8:572–5.Google Scholar
  20. 20.
    Xie L, Wang J, Zhang J, et al. Identification and in vitro antifungal susceptibility of Penicillium marneffei in yeast phase. Chin J Infect Control. 2016;15(12):934–8.Google Scholar
  21. 21.
    Cristina M, Patriza P, Alessanda G, et al. Discontinuation of primary prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus type-1 infections: the charges in opportunistic prophylaxis study. Infect Dis. 2000;18(5):1635–42.Google Scholar

Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Ying-ge Wang
    • 1
  • Jin-mei Cheng
    • 1
  • Hai-bo Ding
    • 2
  • Xi Lin
    • 1
  • Guo-hao Chen
    • 1
  • Mei Zhou
    • 3
  • Sheng-nan Ye
    • 1
  1. 1.Department of Otorhinolaryngology, The First Affiliated Hospital of Fujian Medical UniversityFujian Otorhinolaryngology InstituteFuzhouChina
  2. 2.Department of RespirationThe First Affiliated Hospital of Fujian Medical UniversityFuzhouChina
  3. 3.Department of Health InformationThe First Affiliated Hospital of Fujian Medical UniversityFuzhouChina

Personalised recommendations