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Mycopathologia

, Volume 182, Issue 3–4, pp 397–402 | Cite as

A Case Report of Penile Infection Caused by Fluconazole- and Terbinafine-Resistant Candida albicans

Article

Abstract

Candida albicans is the most common pathogen that causes balanoposthitis. It often causes recurrence of symptoms probably due to its antifungal resistance. A significant number of balanitis Candida albicans isolates are resistant to azole and terbinafine antifungal agents in vitro. However, balanoposthitis caused by fluconazole- and terbinafine-resistant Candida albicans has rarely been reported. Here, we describe a case of a recurrent penile infection caused by fluconazole- and terbinafine-resistant Candida albicans, as well as the treatments administered to this patient. The isolate from the patient was tested for drug susceptibility in vitro. It was sensitive to itraconazole, voriconazole, clotrimazole and amphotericin B, but not to terbinafine and fluconazole. Thus, oral itraconazole was administrated to this patient with resistant Candida albicans penile infection. The symptoms were improved, and mycological examination result was negative. Follow-up treatment of this patient for 3 months showed no recurrence.

Keywords

Candida albicans Penile infection Resistance Terbinafine Fluconazole Itraconazole 

Notes

Acknowledgments

This work was kindly supported by the Guangdong Natural Science Foundation (2015A030310035) and Guangdong Provincial Health Research Fund (A2013388).

We sincerely thank Dr. Mai Junhua for his assistance in English revision.

Compliance with Ethical Standards

Conflict of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Yongxuan Hu
    • 1
  • Yanqing Hu
    • 1
  • Yan Lu
    • 1
  • Shiyun Huang
    • 1
  • Kangxing Liu
    • 1
  • Xue Han
    • 1
  • Zuhao Mao
    • 1
  • Zhong Wu
    • 1
  • Xianyi Zhou
    • 1
  1. 1.Department of Dermatology and VenerologyThe 3rd Affiliated Hospital of Southern Medical UniversityGuangzhouChina

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