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Mycopathologia

, Volume 181, Issue 5–6, pp 425–433 | Cite as

Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature

  • Marwan M. Azar
  • Roland Assi
  • Natalie Patel
  • Maricar F. Malinis
Article

Abstract

In immunocompromised patients, invasive molds such as Aspergillus and Mucor can lead to locally aggressive angioinvasive infections that are often life-threatening. A particularly devastating complication is the development of a fungal mycotic aneurysm resulting from invasion of the arterial wall. Due to anatomic contiguity, the sphenoid sinus provides potential access for these fungi, which often colonize the respiratory sinuses, into the cavernous sinus and internal carotid artery (ICA), thus leading to the formation of ICA aneurysms. The ideal treatment of fungal ICA aneurysms includes a combination of surgical debridement and long-term effective antifungal therapy, but the role of endoscopic resection and the duration of antimicrobials are poorly defined. Here, we present the case of a 71-year-old immunocompromised patient who developed an ICA mycotic aneurysm, associated with a proven invasive fungal infection (presumptively Mucorales) of the sphenoid sinuses, as defined by EORTC/MSG criteria, and who survived after undergoing coil embolization with parent vessel sacrifice of the aneurysm in combination with liposomal amphotericin B. We also review the literature for published cases of invasive fungal sphenoid sinusitis associated with mycotic aneurysms of the ICA and provide a comparative analysis .

Keywords

Mycotic aneurysm Fungal Mucormycosis Sphenoid sinusitis 

Notes

Author Contributions

MA collected and analyzed the data, reviewed all relevant literature, and wrote the first draft of the manuscript. RA, NP, and MM edited and revised the manuscript. All authors have seen and approved the final version for submission. All authors contributed significantly to this work.

Compliance with Ethical Standards

Conflict of interest

The authors have no conflicts of interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Section of Infectious Diseases, Department of Internal MedicineYale School of MedicineNew HavenUSA
  2. 2.Department of SurgeryYale University School of MedicineNew HavenUSA
  3. 3.Department of PathologyYale University School of MedicineNew HavenUSA

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