, Volume 181, Issue 3–4, pp 241–246 | Cite as

Infrequent Production of Xanthomegnin by Fungal Strains Recovered from Patients with Ocular Mycoses

  • Havva Gül Ozdemir
  • Hazal Kandemir
  • Akif Çürük
  • Macit Ilkit
  • Seyedmojtaba Seyedmousavi


Mycotoxins are putative virulence factors of fungi that play an important role in the pathogenesis of fungal infections. Mycotoxin production has been used as a diagnostic marker for the early diagnosis of fungal diseases. Using high-performance liquid chromatography, we investigated whether the fungal strains recovered from eye tissue samples obtained from patients with ocular mycoses produced the mycotoxin xanthomegnin. We tested 62 well-characterized strains of fungi, including Aspergillus spp. (n = 14), Exophiala spp. (n = 9), Fusarium spp. (n = 15), and several molds (n = 24). All isolates were identified to the species level using PCR and DNA sequencing of rRNA genes. We detected xanthomegnin activity (0.02 µg/ml) in one of the three Aspergillus flavus strains. However, we were unable to detect xanthomegnin in any of the other 61 fungal strains. Our result suggests that xanthomegnin production was infrequent in fungal strains recovered from patients with ocular mycoses.


Early diagnosis Ophthalmic fungal strains Pathogenicity Xanthomegnin 



The strains used in this study were provided by Havva Gül Ozdemir, and xanthomegnin and chromatography columns were provided by the Research Fund of Çukurova University (Project no: TF2013YL9). We also appreciate Miss Esin Sönmez for her excellent technical assistance during this study.

Compliance with Ethical Standard

Conflict of interest

Seyedmojtaba Seyedmousavi received research from Gilead Sciences from Astellas Pharma B.V. and Gilead Sciences. All the other authors have no competing interests.


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Havva Gül Ozdemir
    • 1
  • Hazal Kandemir
    • 2
  • Akif Çürük
    • 3
  • Macit Ilkit
    • 2
  • Seyedmojtaba Seyedmousavi
    • 4
    • 5
    • 6
  1. 1.Division of Ophthalmology, Medicosocial Health CenterUniversity of ÇukurovaSarıçamTurkey
  2. 2.Division of Mycology, Department of Microbiology, Faculty of MedicineUniversity of ÇukurovaAdanaTurkey
  3. 3.Department of Biochemistry, Faculty of MedicineUniversity of ÇukurovaAdanaTurkey
  4. 4.Department of Medical MicrobiologyRadboud UMCNijmegenThe Netherlands
  5. 5.Department of Medical Microbiology and Infectious DiseasesErasmus MCRotterdamThe Netherlands
  6. 6.Invasive Fungi Research CenterMazandaran University of Medical SciencesSariIran

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