, Volume 181, Issue 3–4, pp 273–277 | Cite as

The First Case of Total Dystrophic Onychomycosis Caused by Aspergillus clavatus Resistant to Antifungal Drugs

  • Mehraban Falahati
  • Aynaz Ghojoghi
  • Mahdi Abastabar
  • Zeinab Ghasemi
  • Shirin Farahyar
  • Maryam Roudbary
  • Mohammad Taghi Hedayati
  • Mojtaba Taghizadeh Armaki
  • Akbar Hoseinnejad


Onychomycosis is a common fungal infection of nails which is mainly caused by dermatophyte species and less often by yeasts and non-dermatophyte molds. We present a case of onychomycosis due to Aspergillus clavatus for the first time worldwide. The patient was an immunocompetent 32-year-old woman who identified with Psoriasis of the nail. The presence of A. clavatus in a nail sample was confirmed using microscopic and culture analysis followed by PCR of the β-tubulin gene. After antifungal susceptibility test, it is revealed that the isolate was resistant to the majority of common antifungal drugs, but finally the patient was treated with itraconazole 200 mg daily. A. clavatus and drug-resistant A. clavatus have not previously been reported from onychomycosis.


Aspergillus clavatus PCR of the β-tubulin gene Resistant to antifungal drugs 



The authors thank Dr. Saham Ansari for his technical assistance.

Compliance with Ethical Standards

Conflict of interest

The authors report no conflict of interests.


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Mehraban Falahati
    • 1
  • Aynaz Ghojoghi
    • 1
  • Mahdi Abastabar
    • 3
  • Zeinab Ghasemi
    • 2
  • Shirin Farahyar
    • 1
  • Maryam Roudbary
    • 1
  • Mohammad Taghi Hedayati
    • 3
  • Mojtaba Taghizadeh Armaki
    • 3
  • Akbar Hoseinnejad
    • 3
  1. 1.Department of Medical Mycology, School of MedicineIran University of Medical SciencesTehranIran
  2. 2.Department of Medical Mycology, School of MedicineTehran University of Medical SciencesTehranIran
  3. 3.Invasive Fungi Research Center (IFRC), Department of Medical Mycology and Parasitology, School of MedicineMazandaran University of Medical SciencesSariIran

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