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The First Case of Total Dystrophic Onychomycosis Caused by Aspergillus clavatus Resistant to Antifungal Drugs

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Abstract

Onychomycosis is a common fungal infection of nails which is mainly caused by dermatophyte species and less often by yeasts and non-dermatophyte molds. We present a case of onychomycosis due to Aspergillus clavatus for the first time worldwide. The patient was an immunocompetent 32-year-old woman who identified with Psoriasis of the nail. The presence of A. clavatus in a nail sample was confirmed using microscopic and culture analysis followed by PCR of the β-tubulin gene. After antifungal susceptibility test, it is revealed that the isolate was resistant to the majority of common antifungal drugs, but finally the patient was treated with itraconazole 200 mg daily. A. clavatus and drug-resistant A. clavatus have not previously been reported from onychomycosis.

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Acknowledgments

The authors thank Dr. Saham Ansari for his technical assistance.

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Authors and Affiliations

  1. Department of Medical Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Mehraban Falahati, Aynaz Ghojoghi, Shirin Farahyar & Maryam Roudbary

  2. Department of Medical Mycology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Zeinab Ghasemi

  3. Invasive Fungi Research Center (IFRC), Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, P.O. Box 48175-1665, Sari, Iran

    Mahdi Abastabar, Mohammad Taghi Hedayati, Mojtaba Taghizadeh Armaki & Akbar Hoseinnejad

Authors
  1. Mehraban Falahati
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  2. Aynaz Ghojoghi
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  3. Mahdi Abastabar
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  4. Zeinab Ghasemi
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  9. Akbar Hoseinnejad
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Correspondence to Mahdi Abastabar.

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Falahati, M., Ghojoghi, A., Abastabar, M. et al. The First Case of Total Dystrophic Onychomycosis Caused by Aspergillus clavatus Resistant to Antifungal Drugs. Mycopathologia 181, 273–277 (2016). https://doi.org/10.1007/s11046-015-9954-6

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  • DOI: https://doi.org/10.1007/s11046-015-9954-6

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