, Volume 178, Issue 5–6, pp 395–401 | Cite as

The Role of Interleukin-1 Family Members in the Host Defence Against Aspergillus fumigatus



The interleukin (IL)-1 family consists of 11 members, which all play significant roles in regulating inflammatory responses in the host. IL-1α and IL-1β exert potent pro-inflammatory effects and are key players in the recruitment of neutrophils to the site of inflammation. Protective anti-Aspergillus host responses during the early stages of invasive aspergillosis are critically dependent on neutrophil recruitment, and several lines of evidence support that there is an important role for IL-1 in this process. However, IL-1-mediated inflammation needs to be tightly regulated, since uncontrolled inflammation can result in inflammatory pathology and thereby be detrimental for the host. Aspergillus-induced IL-1-mediated inflammation could therefore be amendable for IL-1 blockade under specific circumstances. This review describes the current understanding of the role of IL-1 family members in the host response against Aspergillus fumigatus and highlights the importance of balanced IL-1 responses in aspergillosis.


IL-1 Inflammasome Aspergillosis Genetic susceptibility Chronic granulomatous disease Cytokines 



F. L. van de Veerdonk was supported by a Veni Grant of the Netherlands Organization for Scientific Research, and a NCMLS Grant from RUNMC.


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© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Internal MedicineRadboud University Medical CenterNijmegenThe Netherlands

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