, Volume 175, Issue 1–2, pp 147–151 | Cite as

Assessment of Plant Lectin Antifungal Potential Against Yeasts of Major Importance in Medical Mycology

  • Gabriel Baracy Klafke
  • Gustavo Marçal Schmitt Garcia Moreira
  • Leonardo Garcia Monte
  • Juliano Lacava Pereira
  • Tchana Martinez Brandolt
  • Melissa Orzechowski Xavier
  • Tatiane Santi-Gadelha
  • Odir Antonio Dellagostin
  • Luciano da Silva Pinto


The search for new compounds with antifungal activity is accelerating due to rising yeast and fungal resistance to commonly prescribed drugs. Among the molecules being investigated, plant lectins can be highlighted. The present work shows the potential of six plant lectins which were tested in vitro against yeasts of medical importance, Candida albicans, Candida tropicalis, Candida parapsilosis, Cryptococcus gattii, Cryptococcus neoformans, Malassezia pachydermatis, Rhodotorula sp. and Trichosporon sp. Broth microdilution susceptibility testing was performed in accordance with standard protocols to evaluate antifungal activity. Minimum inhibitory concentration (MIC) was determined at 80 % yeast growth inhibition, whereas the minimum fungicidal concentration (MFC) was evaluated after making the subcultures of each dilution. Only C. parapsilosis growth was inhibited by the lectins tested. Abelmoschus esculentus lectin showed the highest MIC (0.97 μg ml−1). Lectins from Canavalia brasiliensis, Mucuna pruriens and Clitoria fairchildiana presented the highest MFC at (3.90 μg ml−1). These results encourage further studies with wider yeast strain selections, and open new perspectives for the development of pharmacological molecules.


Yeast diseases Candida sp. Abelmoschus esculentus Lectin 



We acknowledge CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) for the financial support and the scholarship granted to G.B. Klafke and L.G. Monte; and FAPERGS (Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul) for the scholarship granted to G.M.S.G. Moreira.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Gabriel Baracy Klafke
    • 1
    • 2
  • Gustavo Marçal Schmitt Garcia Moreira
    • 1
  • Leonardo Garcia Monte
    • 1
  • Juliano Lacava Pereira
    • 2
  • Tchana Martinez Brandolt
    • 2
  • Melissa Orzechowski Xavier
    • 2
  • Tatiane Santi-Gadelha
    • 3
  • Odir Antonio Dellagostin
    • 1
  • Luciano da Silva Pinto
    • 1
    • 4
  1. 1.Núcleo de Biotecnologia, Centro de Desenvolvimento TecnológicoUniversidade Federal de PelotasPelotas cityBrazil
  2. 2.Laboratório de Micologia, Faculdade de MedicinaUniversidade Federal do Rio GrandeRio Grande cityBrazil
  3. 3.Departamento de Biologia MolecularUniversidade Federal da ParaíbaJoão Pessoa cityBrazil
  4. 4.Laboratório de Biotecnologia Vegetal e Proteômica, Núcleo de Biotecnologia, Centro de Desenvolvimento TecnológicoUniversidade Federal de PelotasCapão do LeãoBrazil

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