, Volume 173, Issue 1, pp 69–71 | Cite as

Do Candida spp. “Read” Nietzsche? Can Xenobiotics Modulate their Aggressiveness? Proposition that Chemicals may Interfere in their Virulence Attributes

  • Edvaldo Antonio Ribeiro Rosa


As well as the host, opportunist Candida spp. enface all sorts of exogenous chemicals, so-called xenobiotics. It is plausible that xenobiotics exert some effects on such microorganisms; among them, the modulation of virulence attributes.


Candida spp. Virulence Xenobiotics 


  1. 1.
    Ellepola AN, Samaranayake LP. Oral candidal infections and antimycotics. Crit Rev Oral Biol Med. 2000;11(2):172–98.PubMedCrossRefGoogle Scholar
  2. 2.
    Ueta E, Tanida T, Yoneda K, Yamamoto T, Osaki T. Increase of Candida cell virulence by anticancer drugs and irradiation. Oral Microbiol Immunol. 2001;16(4):243–9.PubMedCrossRefGoogle Scholar
  3. 3.
    Ilbäck NG, Friman G. Interactions among infections, nutrients and xenobiotics. Crit Rev Food Sci Nutr. 2007;47(5):499–519.PubMedCrossRefGoogle Scholar
  4. 4.
    Baboni FB, Barp D, Izidoro AC, Samaranayake LP, Rosa EA. Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke. Mycopathologia. 2009;168(5):227–35.PubMedCrossRefGoogle Scholar
  5. 5.
    Baboni FB, Guariza Filho O, Moreno AN, Rosa EA. Influence of cigarette smoke condensate on cariogenic and candidal biofilm formation on orthodontic materials. Am J Orthod Dentofacial Orthop. 2010;138(4):427–34.PubMedCrossRefGoogle Scholar
  6. 6.
    Mores AU, Souza RD, Cavalca L, de Paula E, Carvalho A, Gursky LC, Rosa RT, Samaranayake LP, Rosa EA. Enhancement of secretory aspartyl protease production in biofilms of Candida albicans exposed to sub-inhibitory concentrations of fluconazole. Mycoses. 2011;54(3):195–201.PubMedCrossRefGoogle Scholar
  7. 7.
    McCool L, Mai H, Essmann M, Larsen B. Tetracycline effects on Candida albicans virulence factors. Infect Dis Obstet Gynecol. 2008; 493508.Google Scholar
  8. 8.
    Uittamo J, Siikala E, Kaihovaara P, Salaspuro M, Rautemaa R. Chronic candidosis and oral cancer in APECED-patients: production of carcinogenic acetaldehyde from glucose and ethanol by Candida albicans. Int J Cancer. 2009;124(3):754–6.PubMedCrossRefGoogle Scholar
  9. 9.
    Carvalho AP, Gursky LC, Rosa RT, Rymovicz AU, Campelo PM, Grégio AM, Koga-Ito CY, Samaranayake LP, Rosa EA. Non-steroidal anti-inflammatory drugs may modulate the protease activity of Candida albicans. Microb Pathog. 2010;49(6):315–22.PubMedCrossRefGoogle Scholar
  10. 10.
    Ying S, Qing S, Chunyang L. The effect of gentian violet on virulent properties of Candida albicans. Mycopathologia. 2010;169(4):279–85.PubMedCrossRefGoogle Scholar
  11. 11.
    Tsang CS, Hong I. HIV protease inhibitors differentially inhibit adhesion of Candida albicans to acrylic surfaces. Mycoses. 2010;53(6):488–94.PubMedCrossRefGoogle Scholar
  12. 12.
    van de Kerkhof EG, de Graaf IA, Groothuis GM. In vitro methods to study intestinal drug metabolism. Curr Drug Metab. 2007;8(7):658–75.PubMedCrossRefGoogle Scholar
  13. 13.
    van de Kerkhof EG, Ungell AL, Sjöberg AK, de Jager MH, Hilgendorf C, de Graaf IA, Groothuis GM. Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with using chamber preparations. Drug Metab Dispos. 2006;34(11):1893–902.PubMedCrossRefGoogle Scholar
  14. 14.
    de Graaf IA, de Kanter R, de Jager MH, Camacho R, Langenkamp E, van de Kerkhof EG, Groothuis GM. Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction. Drug Metab Dispos. 2006;34(4):591–9.PubMedCrossRefGoogle Scholar
  15. 15.
    Fatta-Kassinos D, Kalavrouziotis IK, Koukoulakis PH, Vasquez MI. The risks associated with wastewater reuse and xenobiotics in the agroecological environment. Sci Total Environ. 2010. doi: 10.1016/j.scitotenv.2010.03.036.
  16. 16.
    Goswami R, Ghosh D, Saha DR, Padhy PK, Mazumder S. Effect of acute and chronic arsenic exposure on growth, structure and virulence of Aeromonas hydrophila isolated from fish. Microb Pathog. 2011;50(2):63–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Sionov E, Chang YC, Garraffo HM, Kwon-Chung KJ. Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence. Antimicrob Agents Chemother. 2009;53(7):2804–15.PubMedCrossRefGoogle Scholar
  18. 18.
    Ilbäck NG, Frisk P, Friman G. Effects of xenobiotics and nutrients on host resistance studied in experimental human infections adapted to rodents. J Pharmacol Toxicol Methods. 2008;58(3):179–88.PubMedCrossRefGoogle Scholar
  19. 19.
    Nishino K, Yamaguchi A. Role of xenobiotic transporters in bacterial drug resistance and virulence. IUBMB Life. 2008;60(9):569–74.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.The Pontifical Catholic University of Paraná, Biological and Health Sciences CenterXenobiotics Research UnitCuritibaBrazil

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